skf1

SKF1 is a suppressor of the ability of FK506. SKF1 inhibits cell growth in the presence of high levels of NaCl, induces cell death in low salt conditions, interacts directly with yeast mitochodria.

Epristeride (ONO-9302) 是具有口服活性、选择性和非竞争性类固醇 5-α-还原酶亚型2抑制剂，抑制SR 同工酶 2。Episteride 可减小前列腺大小并改善良性前列腺增生男性的症状。Episteride 诱导大鼠腹侧前列腺萎缩和凋亡。

Pobilukast (SKF 104353) 是一种选择性半胱氨酰白三烯受体拮抗剂，可阻断磷脂酰肌醇代谢和白三烯D诱导的血栓素合成，可用于研究过度心肌再灌注损伤 （MI R） 大鼠限制心肌损伤。

Topotecan hydrochloride (NSC609699) 是一种具有抗癌活性的拓扑异构酶I 抑制剂。

Ropinirole hydrochloride (SKF-101468A) 是D3 D2受体激动剂，对 D2受体的Ki=29 nM。它对 hD2，hD3和 hD4受体的pEC50分别为 7.4、8.4 和 6.8。它对 D1受体没有亲和力。它对帕金森氏病具有潜在的研究价值。

Beta-Sitosterol (SKF 14463) 属于天然产物，是一种植物甾醇，广泛存在于植物界。Beta-Sitosterol 的摄人量与许多慢性病的发生率有关系，比如具有明显降低血清胆固醇的功效。

Topotecan (NSC-609669) 是一种拓扑异构酶 I 抑制剂，通过抑制 DNA 拓扑异构酶起抗肿瘤作用，可用于治疗卵巢癌。

GSK-F1 (PI4KA inhibitor-F1) 是一种新型强效 PI4KA 抑制剂。

Topotecan acetate 是一种拓扑异构酶 (topoisomerase) 的抑制剂。

SK&F 103784 is a vasopressin antagonist.

SK&F 107260 is an RGD-containing peptide. It is a potent GP IIb IIIa antagonist and a vitronectin antagonist.

SK&F 104976 is a 32-carboxylic acid derivative of lanosterol. It was found to be a potent lanosterol 14 alpha-demethylase (14 alpha DM) inhibitor.

SKF-107457 is an HIV protease type 1 inhibitor. It is a hexapeptide substrate analog with the scissile bond being replaced by a hydroxy ethylene isostere.

F 107461 is a hydroxyethylene dipeptide isostere.

Skf 107457 is a hexapeptide substrate analog with the scissile bond being replaced by a hydroxyethylene isostere.

SKF 100398, also known as d(CH2)5Tyr(Et)VAVP, is a particular analog of arginine vasopressin (AVP). It acts as a specific antagonist, specifically targeting the antidiuretic effect caused by both exogenous and endogenous AVP.

(3S)-GSK-F1是一种选择性PI4KIIIα抑制剂，pIC50=8.3。

Dibenamine is an alpha adrenergic antagonist that blocks basal and histamine-stimulated gastric acid secretion.

PBT434 is a novel, brain-penetrant, small molecule inhibitor of α-synuclein aggregation. In transgenic animal models of Parkinson disease (A53T) and MSA (PLP-α-Syn), PBT434 reduced α-synuclein aggregation, preserved neurons and improved motor function. Glial cell inclusions were also reduced in a murine MSA model. PBT434 is thought to act by redistributing reactive iron across membranes, thereby blocking intracellular protein aggregation and oxidative stress. The affinity of PBT434 for iron is greater than that of α-synuclein but lower than that of iron trafficking proteins, e.g., ferritin.

RU 24969 succinate 是5-HT 的受体激动剂，对 5-HT1B 和 5-HT1A 的Ki 值分别为 0.38 和 2.5 nM。RU 24969 succinate 可减少液体消耗并增加向前运动。RU 24969 succinate 可用于神经系统疾病的研究。

N-Despropyl ropinirole is an active metabolite of the dopamine D2 receptor agonist ropinirole. It increases extracellular acidification rates in CHO cells expressing human dopamine D2, D3, and D4 receptors (EC50s = 0.63, 0.063, and 1.23 µM, respectively). N-Despropyl ropinirole is also a potential impurity found in commercial preparations of ropinirole.