sjfα

SJFα (SJF alpha) 是一种由一个E3 泛素连接酶连接蛋白水解调节剂形成的 PROTAC，可降解 p38α和 p38δ，可用于研究癌症。

SJF620 is a potent degrader of PROTAC BTK(DC50 : 7.9 nM).

SJF 1521 是一种属于 PROTAC 的 EGFR 降解剂，能够选择性降解 EGFR，同时保留 HER2。

c-MET degrader. Comprises MET inhibitor foretinib (GSK 1363089; Cat. No. 6056) joined by a linker to a von Hippel-Lindau (VHL) recruiting ligand. Degrades c-MET within 6 hours in vitro. Inhibits agonist-driven AKT phosphorylation and GTL16 cell proliferation (IC50 = 66.7 nM). Also degrades exon-14-deleted c-MET in Hs746T cells.

SJF 0661 is the negative control for SJF 0628. Binds BRAF without inducing degradation.

SJFδ is a 10-atom linker PROTAC that selectively degrades p38δ with a DC50 of 46.17 nM, without degrading p38α, p38β, or p38γ[1].

Potent EGFR Degrader (DC50 values are 39.2 nM for wild-type EGFR in OVCAR8 cells and 736 nM for Exon20Ins mutated EGFR in HeLa cells). Also degrades HER2. Comprises the EGFR inhibitor lapatinib (Cat. No. 6811) joined by a linker to a von Hippel-Lindau (VHL) recruiting ligand. Inhibits proliferation of HER2-driven breast cancer cell lines (IC50 = 102 nM for SKBr3 cells).

SJF620 hydrochloride，作为一种连接Cereblon配体和Btk配体的PROTAC，具备DC50值为7.9 nM。该化合物含Lenalidomide类似物，能有效募集CRBN。