shu9119

SHU 9119 acetate 是众所周知的人黑皮质素 3 和 4 (hMC3R, hMC4R) 受体拮抗剂和部分 hMC5R 激动剂。人 MC3R、MC4R 和 MC5R 的 IC50 值分别为 0.23、0.06 和 0.09 nM。

SHU 9119 is an effective human melanocortin 3 and 4 receptors (MC3 4R) antagonist and a partial MC5R agonist (IC50: 0.23, 0.06, and 0.09 nM for human MC3R, MC4R and MC5R, respectively).

Melanocortin (MC) 3-MSH (Melanocyte-Stimulating Hormone) is believed to signal through the MC 3 receptor. It induces a sustained increase in intracellular free calcium levels ([Ca2+]i) in a subpopulation of pituitary cells. Most of the cells responding to