r-48

Chlornaphazine is an antineoplastic and has been identified as a human carcinogen.

SR-4835 是一种 ATP 竞争性的 CDK12/CDK13高选择性抑制剂。它与破坏 DNA 的化学疗法和 PARP 抑制剂协同作用，并引起三阴性乳腺癌细胞凋亡。

FR-48217 is an immunoactive peptide that inhibits multiplication of HSV-1 and HSV-2.

WRR-483, an analogue of K-11777, is a potent and selective cysteine protease inhibitor with trypanocidal activity in cell culture and animal model with comparable efficacy to K11777. WRR-483 demonstrates good potency against cruzain with sensitivity to pH conditions and high efficacy in the cell culture assay. Furthermore, WRR-483 also eradicates parasite infection in a mouse model of acute Chagas' disease. WRR-483 binds covalently to the active site cysteine of the protease in a similar manner as other vinyl sulfone-based inhibitors. WRR-483 has potential to be developed as a treatment for Chagas' disease.

HIV-1inhibitor-48 是一种新型的非核苷逆转录酶抑制剂 (NNRTI)，具有抗 HIV-1活性。

ASR-488 可激活 mRNA 结合蛋白 CPEB1，诱导细胞凋亡 (apoptosis) 并抑制膀胱癌的生长。

Meclinertant (SR 48692) 是神经降压素受体-1（NT1）拮抗剂，可阻断神经降压素诱导的兴奋，可用于研究神经系统疾病。

Saredutant(SR 48968,沙瑞度坦)是一种选择性的神经激肽-2（NK2）受体拮抗剂通过阻断 NK2 受体来抑制神经激肽 A 的作用，从而发挥抗抑郁和抗焦虑的效果。

Tubulin inhibitor 48 (compound 16) 是一种微管蛋白抑制剂，具有抗癌特性。在 LN-229 和 Capan-1 细胞中的 IC50 分别为 0.1 和 0.07 μM。

3,5-Dinitrocatechol 是儿茶酚-O-甲基转移酶的有效抑制剂，IC50为 12 nM。它可用于制备钼 (VI)- 3,5-Dinitrocatechol 配合物。

SR48527 is a selective antagonist of NTS1R.

R 487 is a bioactive chemical.

Famotidine propionic acid is a histamine H2-receptor antagonist that inhibits stomach acid production. It is commonly used in the treatment of peptic ulcer disease and gastroesophageal reflux disease.

KRAS G12C inhibitor 48 是一种有效的KRAS G12C 抑制剂，IC50为 639.91 nM。 KRAS G12C inhibitor 48 (0-50 µM) 具有抗增殖活性，对 H358，H23，A549 细胞的 IC50s 分别为 0.796，6.33，16.14 µM.

Endothelin 1 (swine, human), Alexa Fluor 488-labeled 是标记了488 荧光的 Endothelin 1 合成肽。Endothelin 1 (swine, human) 是具有人和猪内皮素 1 序列的合成肽，是有效的内源性血管收缩剂。Endothelin 1 通过两种类型受体 ETA 和 ETB 发挥作用。

DSPE-Fluor 488 是一种磷脂，具有良好的生物相容性和显著的两亲性特征，使其在药物配方中成为主要且合适的剂型或辅料，从而实现更好的治疗效果。DSPE-Fluor 488 可用于药物递送的研究。

DSPE-PEG-Fluor 488, MW 2000 是一种 PEG-染料-脂缀合物，由 DSPE 磷脂与 Fluor 488 染料构成。DSPE 是磷脂，能够在水介质中自发形成胶束，而 Fluor 488 是在荧光显微镜中常用的花菁染料，具有 499 nm 与 520 nm 的激发和发射最大值。聚乙二醇脂质通常用于增强脂质纳米颗粒的稳定性。

DSPE-PEG-Fluor 488, MW 5000 是由 DSPE 磷脂（不饱和磷脂）、Fluor 488（作为荧光素染料在荧光显微镜广泛应用，具有 499 nm 的激发和 520 nm 的发射峰值），以及高分子 PEG 间隔剂组成的 PEG-染料-脂质缀合物。

DSPE-CH2-PEG-Fluor 488, MW 2000 是一种包含 DSPE 基团与 Fluor 488 荧光染料的 PEG 脂质缀合物。DSPE 作为磷酸乙醇胺 (PE) 脂质，常用于脂质体的合成，而 Fluor 488 则是一种荧光染料。

DOPE-PEG-Fluor 488, MW 2000 是一种聚乙二醇化脂质，包含 DOPE 基团和 Fluor 488 荧光基团。DOPE 是不饱和磷脂，Fluor 488 的激发和发射峰值分别为 499 nm 和 520 nm。

DOPE-PEG-Fluor 488, MW 5000 是一种 PEG 类脂质，由 DOPE 磷脂和 Fluor 488 荧光染料组成。

Duvelisib (R enantiomer) hydrochloride (INK1197 R enantiomer HCl) 是 PI3K 抑制剂。Duvelisib (R enantiomer) hydrochloride 是 Duvelisib 的活性较低的对映体。

OUP-186 is a high affinity and human rat species-selective antagonist of histamine H3 receptor. OUP-186 suppressed the proliferation of breast cancer cells. The IC50 values at 48 hours for OUP-186 was approximately 50 μM. OUP-186 potently induced cell dea

IKD-8344 is a macrocyclic dilactone originally isolated from an actinomycete species and has diverse biological activities, including anticancer, antimicrobial, and anthelmintic properties.1,2,3 It is cytotoxic to L5178Y murine leukemia cells (IC50 = 0.54 ng ml).1 IKD-8344 inhibits growth of the mycelial form of C. albicans (MIC = 6.25 μg ml) and potentiates the activity of polymyxin B against the multidrug-resistant pathogenic bacterium B. cenocepacia.2,3 It is active against T. spiralis in vitro and in vivo.1 |1. Minami, Y., Yoshida, K., Azuma, R., et al. Structure of a novel macrodiolide antibiotic IKD-8344. Tetrahedron Lett. 33(48), 7373-7376 (1992).|2. Hwang, E.I., Yun, B.S., Yeo, W.H., et al. Compound IKD-8344, a selective growth inhibitor against the mycelial form of Candida albicans, isolated from Streptomyces sp. A6792. J. Microbiol. Biotechnol. 15(4), 909-912 (2005).|3. Loutet, S.A., El-Halfawy, O.M., Jassem, A.N., et al. Identification of synergists that potentiate the action of polymyxin B against Burkholderia cenocepacia. Int. J. Antimicrob. Agents 46(4), 376-380 (2015).