pseudomonas aeruginosa pa14

SPR206 is a polymyxin analogue and an important class of antibiotic for the treatment of bacterial infections due to multidrug resistant Gram-negative pathogen.

Antibacterialsynergist 3 是一种双效生物膜 (biofilm) 抑制剂，其在PAO1中的IC50为0.40 μM，在PA14中的IC50为1.45 μM。它通过抑制群体感应 (QS) 系统来减少毒力因子的产生，并引起铜绿假单胞菌 PAO1 的铁缺乏。此外，Antibacterialsynergist 3 能增强小鼠伤口感染模型中Tobramycin和Ciprofloxacin的疗效，适用于研究铜绿假单胞菌感染。

SPR206 acetate is a polymyxin analog that exhibits antibiotic activity against Gram-negative pathogens, including multidrug-resistant (MDR) variants. By interacting with the outer membrane of the bacterium, SPR206 acetate effectively combats bacterial infections. Notably, SPR206 acetate demonstrates significant efficacy with minimum inhibitory concentration (MIC) values of 0.125 mg L against Pseudomonas aeruginosa Pa14 and Acinetobacter baumannii NCTC13301.