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Search Results for " polymorphonuclear leukocytes "

24

抑制剂 & 化合物

4

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T27026	CJ-13,610 CJ 13610,CJ-13610	Lipoxygenase	Metabolism
	CJ-13,610 是一种具有口服活性的非氧化还原型 5-脂氧合酶 (5-LOX) 抑制剂。 CJ-13,610 抑制白三烯 B4 的生物合成并调节巨噬细胞中 IL-6 mRNA 的表达。
T7739	L-Leucyl-L-Leucine methyl ester hydrochloride Leu-Leu-ome hydrochloride	Others; Endogenous Metabolite	Metabolism; Others
	L-Leucyl-L-Leucine methyl ester hydrochloride (Leu-Leu-ome hydrochloride) 是一种人单核细胞或多形核白细胞产生的 L-亮氨酸甲酯的二肽缩合产物，能够选择性消除具有细胞毒性潜能的淋巴细胞，也能够诱导溶酶体途径应激。
T22946	LY255283 LY 255283	Leukotriene Receptor	GPCR/G Protein
	LY255283 是白三烯 B4 (LTB4) 受体的特异性拮抗剂，抑制人外周血多形核白细胞和由钙离子载体 A23187 激活的单核细胞中 LTB(4) 的产生。
T68166	Traxanox	Others	Others
	Traxanox 是一种可口服的利尿剂。Traxanox 在体外增强小鼠腹膜巨噬细胞或大鼠腹膜多形核白细胞对酵母颗粒的吞噬作用。Traxanox 对抑制BALB/c小鼠抗体产生的恢复作用。
T36879L	H-Leu-Leu-OMe . HBr H-Leu-Leu-OMe . HBr (16689-14-8 Free base)	Others	Others
	H-Leu-Leu-OMe . HBr 是由人单核细胞或多形核白细胞产生的L-亮氨酸甲酯的二肽缩合产物。 H-Leu-Leu-OMe . HBr 诱导内溶酶体途径应激并选择性地消除具有细胞毒性潜力的淋巴细胞。
T68166L	Traxanox TFA Traxanox TFA(58712-69-9 Free base)	Others	Others
	Traxanox TFA 是一种可口服的利尿剂。Traxanox TFA 在体外增强小鼠腹膜巨噬细胞或大鼠腹膜多形核白细胞对酵母颗粒的吞噬作用。Traxanox TFA 对抑制BALB/c小鼠抗体产生的恢复作用。
T24305	L 651142 L651,142,L651142,L-651,142,L 651,142,L-651142
	L 651142 is a weak inhibitor of the platelet-activating factor receptor. It is also binding to polymorphonuclear leukocytes.
T69110	Aseanostatin P5
	Aseanostatin P5 inhibits myeloperoxidase (MPO) release from human polymorphonuclear leukocytes.
T27408	Gea 3162 Gea3162,Gea-3162
	Gea 3162 is a potent inhibitor of ADP-induced platelet aggregation in platelet rich plasma (PRP). GEA 3162 stimulates cGMP production in granulocytes, platelets, and polymorphonuclear leukocytes.
TP2395	Nph-peptide
	Nph-peptide can be used for photoaffinity labeling of the N-formyl peptide receptor site of intact human polymorphonuclear leukocytes.
T15825	LY 178002	Retinoid Receptor	Metabolism
	LY 178002 is an effective inhibitor of 5-lipoxygenase (5-LPO), phospholipase A2 (IC50: 0.6 μM for 5-lipoxygenase). LY 178002 also inhibits cellular production of LTB4 by human polymorphonuclear leukocytes and displays relatively weak inhibition on cycloox
T37460	Lipoxin B4 Lipoxin B4
	Lipoxin B4 (LXB4) is a positional isomer of LXA4 produced by the metabolism of 15-HETE or 15(S)-HpETE by human leukocytes. At a concentration of 100 nM, LXB4 inhibits polymorphonuclear leukocyte (PMN) migration stimulated by leukotriene B4 and inhibits LTB4-induced adhesion of PMNs with an IC50 value of 0.3 nM.
T21962	HZ52
	HZ52 是一种有效可逆的5-脂氧合酶(5-LO)抑制剂，在完整的人类多形核白细胞中可阻断白三烯的合成，IC50为 0.7 μM。
T38308	Lipoxin B4 methyl ester
	Lipoxin B4 (LXB4) methyl ester is a lipid soluble prodrug form of the transcellular metabolite LXB4 . LXB4 is a positional isomer of LXA4 produced by the metabolism of 15-HETE or 15-HpETE by human leukocytes. At a concentration of 100 nM, LXB4 inhibits polymorphonuclear leukocyte (PMN) migration stimulated by leukotriene B4 and inhibits LTB4-induced adhesion of PMNs with an IC50 value of 0.3 nM.
T37649	5(S),12(S)-DiHETE
	5(S),12(S)-DiHETE is a natural bioactive lipid derived from arachidonic acid . It is synthesized by glycogen-induced rabbit peritoneal polymorphonuclear leukocytes (PMNLs) incubated with AA. 5(S),12(S)-DiHETE can be produced by successive oxygenation of AA by 5-lipoxygenase (5-LO) in platelets and 12-LO in leukocytes. It can also be synthesized from 12(S)-HETE by 5-LO, in the presence of 5-LO activating protein (FLAP), activated with calcium ionophore. 5(S),12(S)-DiHETE is an epimer of leukotrie...
T37382	1,2,3-Trieicosapentaenoyl-rac-glycerol
	1,2,3-Trieicosapentaenoyl-rac-glycerol (EPA-TG) is a glycerol ester of eicosapentaenoic acid , which is an ω-3 fatty acid. An EPA-TG emulsion, administered i.v., lowers leukotriene B4 production by 40% in polymorphonuclear leukocytes from rabbits and reduces platelet aggregation. It suppresses natural killer cell activity both in vitro and in vivo, in human lymphocytes and murine spleens, respectively, with the in vivo effects lasting up to seven days.
T37975	13(S)-HODE-biotin
	13(S)-HODE is the lipoxygenase metabolite of linoleic acid. 13(S)-HODE modulates the platelet-activating factor, leukotriene B4, and formyl-Met-Leu-Phe-induced calcium influx in human polymorphonuclear leukocytes. The mechanism by which 13(S)-HODE elicits its inhibitory effect is still unclear. The use of biotinylated 15(S)-HETE as a probe for detecting binding proteins and/or receptors that specifically bind 15(S)-HETE provides a basis for similar use of 13(S)-HODE-biotin.
T38103	Defensin HNP-3 (human) (trifluoroacetate salt)
	Defensin HNP-3 is a peptide secreted by human polymorphonuclear leukocytes (PMNs) that has antimicrobial properties. It induces lysis of mammalian cells when used at a concentration of 25 μg/mL. It also inhibits growth of E. faecalis (ED50 = 100 nM) and clinical isolates of P. aeruginosa (MIC90 = 4 μM). HNP-3 binds to recombinant HIV-1 envelope glycoprotein (gp120) and human CD4 (Kds = 52.8 and 34.9 nM, respectively). It also binds to recombinant, immobilized human surfactant protein D (SP-D; Kd...
T34917	Traxanox sodium Y 12141,Y12141,Y-12141
	Traxanox sodium 是一种可口服的利尿剂。Traxanox sodium 在体外增强小鼠腹膜巨噬细胞或大鼠腹膜多形核白细胞对酵母颗粒的吞噬作用。Traxanox sodium 对抑制BALB/c小鼠抗体产生的恢复作用。
T71303	Flufenamic Acid-d4
	Flufenamic acid-d4 is intended for use as an internal standard for the quantification of flufenamic acid by GC- or LC-MS. Flufenamic acid is a non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor (IC50s = 3 and 9.3 µM for human COX-1 and COX-2, respectively). Flufenamic acid inhibits TNF-α-induced increases in COX-2 levels and NF-κB activation in HT-29 colon cancer cells in a concentration-dependent manner. It inhibits calcium influx induced by fMLP or A23187 in human polymorphonuclear...
T36423	Leukotriene B5
	Leukotriene B5 (LTB5) is a leukotriene with diverse biological activities. It is a metabolite of eicosapentaenoic acid formed through the 5-lipoxygenase (5-LO) pathway. LTB5 increases contraction of bullfrog lung strips ex vivo in a concentration-dependent manner. In vivo, LTB5 (100 nM) reduces tumor volume in mice injected with Tm1 murine melanoma cells. LTB5 also elicits chemokinesis and lysosomal enzyme release from polymorphonuclear leukocytes (PMNLs) 20- to 30-fold less, and induces platele...
T83669	PMX-53 TFA AcPhe-[Orn-Pro-D-Cyclohexylalanine-Trp-Arg],AcF-[OPdChaWR],3D53
	PMX-53是一种大环型补体5a (C5a) 类肽模拟物及C5a受体的拮抗剂（IC50 = 0.3 µM）。它能抑制C5a诱导的人类分离性多形核白细胞（PMNs）中的髓过氧化物酶（MPO）分泌。在大鼠腹膜亚瑟斯反应模型中，PMX-53（10 mg/kg, p.o.）能够抑制血管渗漏、多形核白细胞浸润以及腹膜TNF-α和IL-6的产生。在3-硝基丙酸（3-NP）诱导的亨廷顿病大鼠模型中，它能减少体重损失和厌食，抑制纹状体退化。PMX-53（3 mg/kg）还能在ApoE-/-小鼠中减小动脉粥样硬化斑块大小和脂质含量。
T35836	PMX-205 (trifluoroacetate salt)
	PMX-205 is a cyclic hexapeptide that acts as a potent antagonist of C5a receptor (C5aR; IC50= 31 nM).1It is orally active and blocks inflammatory signaling and symptoms in animal models of colitis and allergic asthma.2,3PMX-205 is also brain penetrant and reduces neuroinflammation and neurodegeneration in an animal model of Alzheimer's disease.4 1.March, D.R., Proctor, L.M., Stoermer, M.J., et al.Potent cyclic antagonists of the complement C5a receptor on human polymorphonuclear leukocytes. Rela...
T35881	Resolvin E2
	Resolvin E2 (RvE2) is a member of the specialized pro-resolving mediator (SPM) family of bioactive lipids.1It is produced from eicosapentaenoic acidviaan 18-HEPE intermediate, which is formed by aspirin-acetylated COX-2-mediated oxidation of EPA, by 5-lipoxygenase (5-LO) in human polymorphonuclear (PMN) neutrophils.2,3RvE2 (20 ng/animal) inhibits increases in inflammatory exudate neutrophil infiltration in a mouse model of peritonitis induced by zymosan A .3Hepatic RvE2 levels are increased in m...

化合物

Cat.No: T27026

Synonym: CJ 13610,CJ-13610

Target: Lipoxygenase

L-Leucyl-L-Leucine methyl ester hydrochloride

Cat.No: T7739

Synonym: Leu-Leu-ome hydrochloride

Target: Others, Endogenous Metabolite

Cat.No: T22946

Synonym: LY 255283

Target: Leukotriene Receptor

Cat.No: T68166

Target: Others

H-Leu-Leu-OMe . HBr

Cat.No: T36879L

Synonym: H-Leu-Leu-OMe . HBr (16689-14-8 Free base)

Target: Others

Cat.No: T68166L

Synonym: Traxanox TFA(58712-69-9 Free base)

Target: Others

Cat.No: T24305

Synonym: L651,142,L651142,L-651,142,L 651,142,L-651142

Aseanostatin P5

Cat.No: T69110

Cat.No: T27408

Synonym: Gea3162,Gea-3162

Cat.No: TP2395

Cat.No: T15825

Target: Retinoid Receptor

Cat.No: T37460

Synonym: Lipoxin B4

Cat.No: T21962

Lipoxin B4 methyl ester

Cat.No: T38308

5(S),12(S)-DiHETE

Cat.No: T37649

1,2,3-Trieicosapentaenoyl-rac-glycerol

Cat.No: T37382

13(S)-HODE-biotin

Cat.No: T37975

Defensin HNP-3 (human) (trifluoroacetate salt)

Cat.No: T38103

Traxanox sodium

Cat.No: T34917

Synonym: Y 12141,Y12141,Y-12141

Flufenamic Acid-d4

Cat.No: T71303

Cat.No: T36423

Cat.No: T83669

Synonym: AcPhe-[Orn-Pro-D-Cyclohexylalanine-Trp-Arg],AcF-[OPdChaWR],3D53

PMX-205 (trifluoroacetate salt)

Cat.No: T35836

Cat.No: T35881

Cat. No.	Product Name	Target	Signaling Pathways
T4S1422	Praeruptorin E 白花前胡素 E,白花前胡素E	Others; Calcium Channel	Membrane transporter/Ion channel; Metabolism; Others
	Praeruptorin E 是白花前胡中的一种主要成分，是钙拮抗剂，pD2′值为 5.2。
TN4486	Magnolianin	Others	Others
	Magnolianin can inhibit strongly (IC50 = 0.45 uM) 5-HETE formation by die cytosol of guinea pig polymorphonuclear leukocytes.
T13716	(+)-Guaiacin	Others	Others
	(+)-Guaiacin is a compound isolated from the bark of Machilus wangchiana Chun. It shows potent in vitro activities against the release of β-glucuronidase in rat polymorphonuclear leukocytes (PMNs) induced by platelet-activating factor (PAF).
TN4584	Morolic acid	IL Receptor; COX; HIV Protease	Immunology/Inflammation; Microbiology/Virology; Neuroscience; Proteases/Proteasome
	Morolic acid and moronic acid have shown sustained antidiabetic and antihyperglycemic action possibly mediated by an insulin sensitization with consequent changes of glucose, cholesterol and triglycerides, in part mediated by inhibition of 11β-HSD 1. Moro

天然产物

Cat.No: T4S1422

Synonym: 白花前胡素 E,白花前胡素E

Target: Others, Calcium Channel

Cat.No: TN4486

Target: Others

Cat.No: T13716

Target: Others

Cat.No: TN4584

Target: IL Receptor, COX, HIV Protease

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