ns-7

Atrasentan, also known as ABT-627, is a orally available ETA receptor antagonist with potential antineoplastic activity. As a selective antagonist of the endothelin-A (ETA) receptor, atrasentan binds selectively to the ETA receptor, which may result in inhibition of endothelin-induced angiogenesis and tumor cell proliferation.

Dexpramipexole ((R)-Pramipexole) 是利鲁唑的 BTZ 结构类似物，是一种维持线粒体功能和能量产生的线粒体保护剂，可通过上调线粒体自噬减轻心肌缺血 再灌注损伤，可用于治疗肌萎缩侧索硬化症疾病。

Droxinostat (NS 41080) 是HDAC3、HDAC6和HDAC8抑制剂，IC50分别为16.9、2.47和1.46 μM。

Nanangenine F is a drimane sesquiterpene fungal metabolite that has been found inA. nanangensis.1It is active againstB. subtilis(IC50= 78 μg ml) and cytotoxic to NS-1, DU145, and MCF-7 cancer and NFF non-cancerous cells (IC50s = 49, 95, 49, and 84 μg ml, respectively). 1.Lacey, H.J., Gilchrist, C.L.M., Crombie, A., et al.Nanangenines: Drimane sesquiterpenoids as the dominant metabolite cohort of a novel Australian fungus, Aspergillus nanangensisBeilstein J. Org. Chem.152631-2643(2019)