non-hydroxamate

TP0586532 是有效的non-hydroxamate LpxC 抑制剂 (IC50=0.101 μM)。TP0586532具有低心血管风险的特点，对肺炎克雷伯菌有效，包括耐药菌株。

SE-7552, 一种2-(difluoromethyl)-1,3,4-oxadiazole (DFMO) 衍生物，具备口服活性，是一个高选择性非异羟肟酸HDAC6抑制剂，IC50为33 nM。此化合物对所有其他已知HDAC同工酶的选择性高出850倍。SE-7552有效抑制体内多发性骨髓瘤的生长，并在饮食诱导的肥胖小鼠中起到抗肥胖作用。

LpxC-IN-5 is a potent, non-hydroxamate inhibitor of LpxC, which is an enzyme known as UDP-3-O-acyl-N-acetylglucosamine deacetylase. It exhibits an IC50 value of 20 nM. Furthermore, LpxC-IN-5 displays antibacterial activity against various strains including E. coli ATCC25922, P. aeruginosa ATCC27853, K. pneumoniae ATCC13883, and P. aeruginosa 5567. The minimum inhibitory concentration (MIC) values for these strains are 16 μg/mL, 4 μg/mL, 64 μg/mL, and 4 μg/mL, respectively.