nec-1

Necrostatin-1 (Nec-1) 是一种坏死性凋亡抑制剂和 RIP1 抑制剂，具有特异性。Necrostatin-1 抑制 TNF-α 诱导的坏死性凋亡。Necrostatin-1 也可以抑制 IDO。

Necrostatin 2 racemate (Necrostatin-2 racemate) 是一种特异性的RIPK1抑制剂，是一种稳定型 Nec-1。

Cl-Necrostatin-1 is an inhibitor of receptor-interacting protein kinase. It inhibits RIPK1 activity.

Necrostatin-1(Nec-1)（inactive control）为Necrostatin-1的非活性类似物，后者为一种高效的坏死性凋亡抑制剂。

Thalidomide-amine-C11-acid 是一种由Thalidomide 5-fluoride和连接子组成的E3 连接酶配体-连接子复合物。Thalidomide-amine-C11-acid 可用于合成JQAD1。

L-threo-Sphingosine C-18 is a protein kinase C inhibitor.

Lysophosphatidylcholine C19:0 (1-Nonadecanoyl-2-hydroxy-sn-glycero-3-phosphocholine)为具有C19:0酰基链的脂质。该化合物能促进IL-1beta的分泌。

Sphingosine (d18:1), an amino alcohol, is chiefly recognized for its 18-carbon unsaturated hydrocarbon chain. Nevertheless, in mammalian tissues, both sphingosine and its variant, dihydrosphingosine, feature hydrocarbon chains ranging from 12 to 26 carbons. Sphingosine (d15:1) represents a naturally rare variant, serving as an internal standard for chromatographic or spectrometric analyses of sphingoid compounds.

Sphingosine (d16:1), an unconventional sphingolipid, is synthesized through enzymatic reactions starting with the condensation of myristoyl-CoA and serine by serine palmitoyltransferase long-chain base subunit 3 (SPTLC3), which shows a preference for myristoyl-CoA. This compound is found in minute quantities in its free form in human plasma and as a component of various plasma sphingolipids, such as sphingosine-1-phosphate, ceramides, sphingomyelins, and in brain cerebrosides, albeit at lower concentrations than the more common d18:1 sphingoid base. Sphingosine (d16:1) acts as an inhibitor of PKC in mixed micelle assays and diminishes superoxide production triggered by phorbol 12-myristate 13-acetate in isolated human neutrophils, as well as inhibiting the growth of CHO cells with IC50 values of 1 and 3.2 µM, respectively. Additionally, the concentration of sphingolipids containing sphingosine (d16:1) in the plasma is linked to the dietary consumption of saturated fatty acids and protein among ethnic Chinese populations.

18:0-LPS (Lysophosphatidylserine C18:0) 是一种内源性脂质，在磷脂氧化过程中发现。该化合物可能在心血管疾病的研究中具有应用潜力。

Nec-4 is a potent inhibitor of receptor interacting protein 1 (RIP1)(IC50 of 2.6 μM),and is a tricyclic derivative.