kv channels

Oxybutynin (Ditropan) 是一种抗胆碱能药，抑制血管 Kv 通道，IC50为 11.51 μM，可用于治疗尿失禁和膀胱过度活动症。

Oxybutynin chloride (Oxybutynin HCl) 是一种抗胆碱能药物，用于缓解泌尿和膀胱困难。它抑制血管 Kv 通道，IC50为 11.51 μM。

Hymenidin HCl(膜虫素盐酸盐)是一种从Hymeniacidon sp.中分离出的天然生物碱，可作为血清素（5-HT）受体的拮抗剂，膜虫素盐酸盐能够抑制电压门控钾通道（Kv），对CDK5表现出选择性的抑制作用，影响细胞的信号传递，还能够诱导癌细胞的凋亡。

Kv3 modulator 2 is a potent Kv3 channels modulator.has analgesic activity and is used in the prophylaxis or treatment of related disorders.

Kv3 modulator 3 is a selective modulator of Kv3.1 and or Kv3.2 and or Kv3.3 channels .has analgesic activity for use in the prophylaxis o or treatment of pain.

NADP+ is the oxidized form of the electron donor nicotinamide adenine dinucleotide phosphate . It serves as a cofactor in various biological reactions. In addition, the balance between these reduced and oxidized forms plays key roles in diverse cellular functions, including cell survival, the maintenance of redox status, and intracellular signaling. For example, binding of NADP+ to β-subunits of Kv channels activates ion transport, whereas NADPH stabilizes channel inactivation. NADP+ is biosynthesized from NAD+ by NAD kinase, with ATP as the phosphoryl donor.

Photoswitchable Kv channel blocker (IC50 values are 2 and 64 μM at 500 nm and 380 nm respectively). Switches conformation from cis to trans at 500 nm and trans to cis at 380 nm. Exhibits minimal activity at Nav1.2 and L-type Ca2+ channels. Stimulates action potential firing of hippocampal neurons in vitro at 500 nm and restores visual responsiveness in blind mice at 380 nm. Fortin et al (2008) Photochemical control of endogenous ion channels and cellular excitability. Nat.Methods 5 331 PMID:18311146 |Polosukhina et al (2012) Photochemical restoration of visual responses in blind mice. Neuron 75 271 PMID:22841312 |Banghart et al (2009) Photochromic blockers of voltage-gated potassium channels. Angew.Chem.Int.Ed. 48 9097 PMID:19882609

aliotoxin是神经BK型肽基的抑制剂，对Kv通道和钙激活的钾通道能产生特异性抑制。Kaliotoxin对细胞膜电位和神经元兴奋性的调控具有研究意义。其产品编号为 T37808，CAS号为 145199-73-1

MSD-D is an inhibitor of voltage-gated K(+) (Kv) channels Kv1.5.

Phrixotoxin 2为具有高选择性的KV4.2与KV4.3通道阻断剂。

Aam-KTX，一种从蝎子Mesobuthus eupeus毒液中提取的毒性肽类Kv通道抑制剂，对Kv1.3和Kv1.1的IC50值分别为1.1 nM和＞750 nM。Aam-KTX在研究自身免疫性疾病方面显示出潜在应用价值。

VSTx-3是KV通道阻断剂，同时也是TTX敏感钠通道尤其是NaV1.8通道的有效阻断剂。具体而言，其对hNaV1.3通道的IC50为0.19 μM，对hNaV1.7通道的IC50为0.43 μM，对hNaV1.8通道的IC50为0.77 μM。

LY303511, a structural analog of LY294002, selectively inhibits mTOR-dependent phosphorylation of S6K, unlike its counterpart, which acts as a phosphatidylinositol 3-kinase (PI3K) inhibitor. It effectively reduces cell proliferation in human lung epithelial adenocarcinoma cells by hindering G2/M phase progression and suppressing casein kinase 2 activity. Additionally, LY303511 enhances tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) sensitivity in HeLa cells resistant to TRAIL-induced apoptosis and blocks voltage-gated potassium (Kv) channels.

Halofuginone hydrochloride (RU-19110)，Febrifugine的衍生物，作为脯氨酰-tRNA合成酶竞争性抑制剂，其Ki值为18.3 nM。该化合物特异性抑制I型胶原合成，并能通过降低TGF-β活性来减轻骨关节炎症状。同时，Halofuginone hydrochloride 作为有效的肺血管扩张剂，通过激活Kv通道并阻断电压门控、受体操作与存储操作的Ca2+通道发挥作用。此外，它还具有抗疟疾、抗炎、抗癌及抗纤维化的多重生物活性。