kds 2010

SB1-F-21 is an UCHL1 inhibitor.

Tisolagiline(KDS2010)是一种强效、高选择性和可逆的MAO-B抑制剂，IC50=8 nM且具有口服活性，可用于治疗阿尔茨海默病和肥胖症。

KDS2010 is a potent, highly selective, and reversible MAO-B inhibitor which shows 12,500-fold selectivity over MAO-A. KDS2010 overcomes the disadvantages of the irreversible MAO-B inhibitor and significantly attenuates increased astrocytic GABA levels and astrogliosis, thereby enhancing synaptic transmission, and rescuing learning and memory impairments in APP PS1 mice.