j 2156

The ED50 of J-2156 in rats for the relief of mechanical allodynia and mechanical hyperalgesia in the ipsilateral hindpaws was 3.7 and 8.0 mg/kg, respectively. J-2156 is a high potent, selective somatostatin receptor type 4 (SST4 receptor) agonist with IC5

J-2156 TFA是一种选择性的SST4受体(somatostatin receptor type 4)激动剂，对于人和大鼠SST4受体的 IC50分别为0.05 nM和0.07 nM，具有抗炎和镇痛作用，能够降低pERK水平。