hif phd in 1

HIF-PHD-IN-1 is a pharmacological compound that acts as an orally active inhibitor of the hypoxia-inducible factor prolyl hydroxylase domain (HIF-PHD), displaying an IC50 of 54 nM for hHIF-PHD2. Its potential as a therapeutic agent for renal anemia is highly promising.

IOX2 (IOX 2) 是特异性的脯氨酰羟化酶-2 抑制剂，IC50=22 nM。

PHD-1-IN-1 是口服有效的缺氧诱导因子脯氨酰羟化酶结构域 1抑制剂，IC50为 0.034 μM。它与活性位 Fe2+具有独特的单齿结合相互作用，并诱导形成一个 “Arg367-out” 口袋。

HIF-PHD-IN-2 (compound 25) is a highly effective PHD inhibitor, displaying IC50 values below 100 nM for PHD1, PHD2, and PHD3 [1].

HIF-PHD-IN-3 是一种有效的 hiPSC-CM 心脏保护支架，对 HIF-PHD 有潜在的抑制作用，可调节血红素加氧酶-1，可用于研究贫血。