glucose intolerance

Exicorilant is a selective and oral active glucocorticoid receptor (GR) antagonist (Ki: 7 nM) and it also has the potential to overcome adiposity, glucose intolerance, and dyslipidemia.

BDM44768 is an insulin-degrading enzyme (IDE) inhibitor that acts by inducing glucose intolerance.

T-1095A is an active metabolite of T-1095, a potent and selective inhibitor of Na+-glucose cotransporters (SGLTs). Chronic administration of T-1095 (0.1% w w(-1) pellet chow, for 12 weeks) decreased blood glucose and haemoglobin A(1C) levels, and improved

CPT-157633 is a difluoro-phosphonomethyl phenylalanine derivative that acts as a potent inhibitor of the enzyme PTP1B. It effectively prevents the development of glucose intolerance induced by binge drinking.

DS-1558 is a potent and orally available GPR40 agonist.DS-1558 was found to have potent glucose lowering effects during an oral glucose tolerance test in ZDF rats. DS-1558 significantly and dose-dependently improved hyperglycemia and increased insulin secretion during the oral glucose tolerance test in Zucker fatty rats, the model of insulin resistance and glucose intolerance. DS-1558 not only increased the glucose-stimulated insulin secretion by GLP-1 but also potentiated the maximum insulinogenic effects of GLP-1 after an intravenous glucose injection in normal Sprague Dawley rats.

ATF3 inducer 1 是一种高效 ATF3 诱导剂，具有降脂特性和抗高血糖活性，能减轻 HFD 诱导的葡萄糖耐量异常和胰岛素抵抗，缓解 HFD 引发的肝脏脂肪变性，可用于研究肥胖。

Sequoyitol (5-O-Methyl-Myo-Inositol) 来源于植物。它可以改善体内葡萄糖耐量，降低血糖，可用于糖尿病的研究。