fn-1

NCGC00378430 是一种 SIX1 EYA2 相互作用抑制剂。它部分逆转 SIX1 过表达介导的转录和代谢谱，并逆转 SIX1 诱导的 TGF-β 信号传导和上皮-间质转化。在小鼠模型中，它能够抑制 SIX1 介导的乳腺癌转移。

FN-1501-propionic acid, a CDK2 9 ligand, in conjunction with a CRBN ligand, has been utilized in the design of a PROTAC CDK2 9 degrader.

FN-1501 是一种有效的 FLT3 和 CDK 抑制剂，具有抗肿瘤的活性，对 CDK2 cyclin A、CDK4 cyclin D1、CDK6 cyclin D1 和 FLT3 的 IC50值分别为 2.47、0.85、1.96 和 0.28 nM。

AFN-1252 tosylate is an enoyl-ACP Reductase inhibitor.

StA-IFN-1 is an inhibitor of the interferon (IFN) induction pathway with an IC50 value of 4.1 μM in a GFP reporter assay for IFN induction similar to TPCA-1 , which specifically inhibits the IKKβ component of the IFN induction pathway. It does not show inhibitory activity in a GFP reporter assay for IFN signaling in which ruxolitinib , which is specific for the IFN signaling component JAK1, is active. StA-IFN-1 reduces the levels of IFN-β, but not ISG MxA, mRNA, suggesting that it is selective for the IFN induction pathway and not the IFN signaling pathway.

FFN-102 (trifluoroacetate salt) 是一种合成的生物源性神经递质类似物，具有 PH 依赖性荧光和电活性。

AFN-1252 (Debio 1452)是一种FabI 的高效抑制剂，能抑制金黄色葡萄球菌。

AFN-1252, also known as AFN-12520000; API-1252; Debio-1452, is FASII Inhibitor which is potentially for the treatment of acute bacterial skin. AFN-1252 exhibits typical MIC(90) values of ≤0·015 μg ml against diverse clinical isolates of S. aureus, oral absorption, long elimination half-live and efficacy in animal models. AFN-1252 efficiently blocked daptomycin-induced phospholipid decoy production, even in the case of isolates resistant to AFN-1252, which prevented the inactivation of daptomycin and resulted in sustained bacterial killing. In turn, daptomycin prevented the fatty acid-dependent emergence of AFN-1252-resistant isolates in vitr

L524-0366 ([1-(3-chlorophenyl)triazol-4-yl]-thiomorpholino-methanone) 是一种 TWEAK-Fn14 信号级联抑制剂。

Pfn1-IN-C1, an inhibitor of Profilin1 (Pfn1), has been shown to reduce the overall level of cellular filamentous (F)-actin, slow EC migration and proliferation, and inhibit the angiogenic ability of EC both in vitro and ex vivo.

BAY 2666605 是一种具有口服活性的 PDE3A 和 PDE3B 抑制剂，IC50 分别为 87 nM 和 50 nM。 BAY 2666605 具有抗癌作用。

AMPCP is an Ecto-5'-nucleotidase (CD73) inhibitor.

Pfn1-IN-C2, an inhibitor of Profilin1 (Pfn1), has been shown to reduce the overall level of cellular filamentous (F)-actin, slow EC migration and proliferation, and inhibit the angiogenic ability of EC both in vitro and ex vivo.

SC 53606 is a potent and selective antagonist of 5-hydroxytryptamine4 receptor.

QM-FN-SO3是一种具有聚集诱导发射(AIE)活性的近红外(NIR)探针，能穿透大脑屏障，并用于In vivo Aβ斑块检测。该探针展现了超高信噪比、出色的结合亲和力及高效的近红外发射性能。

Dracorhodin perchlorate 是来源于中药血竭的一种天然产物。它抑制细胞生长，并以剂量和时间依赖性方式诱导成纤维细胞凋亡，将细胞周期阻滞在 G1 期，可作为抗乳腺癌的候选药物。

FN-439 TFA为选择性胶原酶1 (collagenase-1) 抑制剂，其对胶原酶-1的IC50为1μM，适用于癌症与炎症研究领域。

Micheliolide 是一种倍半萜内酯，能够抑制各种炎症反应。它能减弱高糖刺激的NF-κB 活化，IκBα的降解，和MCP-1，TGF-β1，FN 在鼠系膜细胞的表达。

FN-439为选择性胶原酶 1 抑制剂，其对胶原酶-1展现出IC50为1 μM的抑制作用，适用于癌症与炎症研究。