est64454 maleic acid salt

EST64454 Maleic acid salt 是EST64454的马来酸盐形式。EST64454是一种用于治疗疼痛的高可溶性σ1受体拮抗剂临床候选药物。

EST64454 is a σ1 receptor (σ1R) antagonist clinical candidate for the treatment of pain. EST64454 shows an outstanding aqueous solubility, which together with its high permeability in Caco-2 cells will allow its classification as a BCS class I compound. It also shows high metabolic stability.

EST64454 hydrochloride (EST64454) 是一种可口服的选择性sigma-1受体拮抗剂，Ki 为 22 nM。它有用于疼痛的研究潜力。