dpc-4

DP-C-4 is a Cereblon-based dual PROTAC for simultaneous degradation of EGFR and PARP[1]. DP-C-4 (1-50 μM; 24 hours) has degradation effects on EGFR and PARP simultaneously in a dose-dependent manner in SW1990 cells[1]. [1]. Mengzhu Zheng, et al. Rational Design and Synthesis of Novel Dual PROTACs for Simultaneous Degradation of EGFR and PARP. J Med Chem. 2021 May 26.

DPC-423 is a factor Xa inhibitor potentially for the treatment of thrombosis.

DPC-681 is a potent and selective HIV protease inhibitor (IC90s: 4 to 40 nM for wild-type HIV-1).

GUN69400（亦称为di-2-pyridylketone 4-cyclohexyl-4-methyl-3-thiosemicarbazone hydrochloride）是一种新型thiosemicarbazone，通过多种机制抑制体内外神经母细胞瘤的生长。