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db 75, db75, nsc 305831, wr-199385

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    TargetMol | Inhibitors_Agonists
  • Furamidine dihydrochloride
    DB 75, DB75, NSC 305831, WR199385,Furamidine HCl
    T2739555368-40-6
    Furamidine is a cell-permeable, selective inhibitor of protein arginine methyltransferase 1 (PRMT1). Furamidine binds to strings of AT base pair sequences in DNA′s minor groove. Furamidine targets the enzyme active site and is primarily competitive with t
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    35日内发货
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  • TargetMol
    Furamidine
    NSC 305831, DB75
    T1133873819-26-8
    Furamidine is also a selective and cell-permeable protein arginine methyltransferase 1 (PRMT1) inhibitor with an IC50 of 9.4 μM. Furamidine is selective for PRMT1 over PRMT5, PRMT6, and PRMT4 (CARM1) (IC50s of 166 μM, 283 μM, and >400 μM, respectively). Furamidine (DB75) is abisbenzamidine derivative and an antiparasite agent. Furamidine is a potent, reversible and competitive tyrosyl-DNA phosphodiesterase 1 (TDP-1) inhibitor. Inhibition of TDP-1 by Furamidine is effective both with single- and double-stranded DNA substrates but is slightly stronger with the duplex DNA.
    • ¥ 10600
    6-8周
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