composition

tert-Butyl 11-aminoundecanoate 是一种属于 PEG 类的 PROTAC linker。它可用于合成一系列 PROTAC 分子。

Theaflavin digallate和乳酸一起可以减少单纯疱疹病毒的传播。

MERS-CoV-IN-1 对冠状病毒的活性具有优异的抑制作用，可用作预防冠状病毒引起疾病的药物组合物。

Miconazole nitrate (R18134 nitrate) 是咪唑类可抗菌的抗真菌剂。

Diethyltoluamide (DEET) 是驱虫剂中常见的活性成分，可保护皮肤，防止蚊虫叮咬。

Butoconazole nitrate (RS 35887) 是一种咪唑类抗真菌药物，可治疗由白色念珠菌引起的阴道感染。它可通过抑制类固醇合成起到抗菌作用。

Br-C10-methyl ester 是一种属于 alkyl ether 类的 PROTAC linker，可用于一系列 PROTAC 分子的合成。PROTAC 分子含有两个通过 linker 连接的不同配体，一种是 VHL 配体部分，另一种是靶蛋白配体。

Monoethyl pimelate 是一种属于 alkyl ether 类的 PROTAC linker 可用于特异性的 BCL-XLPROTAC 降解剂 (S,R,S)-AHPC-Me-C7 ester 的合成。

Lecithin (L-α-Phosphatidylcholine) 被认为是安全的常规磷脂源。磷脂能够改变动物细胞膜的脂肪酸组成和微观结构。

Betaine (trimethylglycine) 是许多食物中发现的天然化合物，也是能够维持正常 DNA 甲基化模式的特性甲基供体。它广泛存在于植物，动物，微生物和丰富的膳食来源中。它能够促进各种肠道微生物抵抗渗透变化，从而改善微生物发酵特性。它也能够作为渗透物，通过防止脱水和渗透失活来维持禽类的细胞水和离子平衡，从而提高禽类对热应激的能力。

Elubiol (dichlorophenyl imidazoldioxolan) 是咪唑类的新型广谱抗真菌产品，可抑制真菌麦角甾醇的生物合成，改变细胞膜中其他脂质化合物的组成。 Elubiol 用于油性皮肤或头皮屑患者的皮肤和头发护理。

1-Stearoyl-rac-glycerol 是一种在 sn-1 位含有硬脂酸的单酰甘油。在偶氮甲烷诱发的小鼠结肠直肠癌模型中，肿瘤组织中的 1-Stearoyl-rac-glycerol水平降低。1-Stearoyl-rac-glycerol 已被用于大鼠透皮递送阿霉素的传递体的组成，导致阿霉素在淋巴结、脾脏和心脏中积聚。

8,9-Epoxy-3-isobutyryloxy-10-(2-methylbutanoyl)thymol is a chemical composition of essential oils from Telekia speciosa. It also shows marked antipro-liferative activity against human cancer cell lines in vitro.

Dazopride is an antiemetic agent.

Retagliptin Phosphate (SP 2086) 是一种选择性、竞争性、口服活性的二肽基肽酶 4 (DPP-4) 抑制剂。Retagliptin phosphate 能够用于 2 型糖尿病 (T2DM) 的研究。

Tos-PEG4-t-butyl ester (Tos-PEG4-Boc) is a PROTAC linker characterized by its PEG composition. This compound plays a crucial role in the synthesis of a range of PROTACs, including BI-3663, a highly selective PTK2 FAK PROTAC. It employs cereblon ligands to target E3 ligases for the degradation of PTK2, exhibiting potent inhibitory activity with an IC50 of 18 nM[1].

Boc-Pip-alkyne-Ph-COOH, a PROTAC linker characterized by its alkyl ether composition, plays a crucial role in synthesizing PROTACs including ARD-266. This compound demonstrates significant efficacy in promoting the degradation of androgen receptor (AR) protein across AR-positive prostate cancer cell lines such as LNCaP, VCaP, and 22Rv1, showcasing DC50 values ranging from 0.2-1 nM[1].

NH2-PEG5-C6-Cl (K-7) is a PROTAC linker characterized by its PEG composition. It can be utilized in the synthesis of various PROTACs, facilitating the degradation of intracellular molecules via autophagy[1].

Phthalimide-PEG4-MPDM-OH, a PROTAC linker with a PEGs composition, has applications in the synthesis of various PROTACs. These PROTACs consist of a linker connecting two distinct ligands: one binds to an E3 ubiquitin ligase, while the other binds to the target protein. By leveraging the intracellular ubiquitin-proteasome system, PROTACs selectively induce the degradation of target proteins [1].

S-(1-Hydroxy-2-methylpropan-2-yl) methanesulfonothioate, an ADC linker, is a glutathione cleavable compound used for the attachment of monoclonal antibodies (mAb) in antibody-drug conjugates (ADCs). It specifically refers to the Alkyl-Chain composition of the linker portion of these molecules [1].

DZ-837 是一种特定针对BCL6的PROTAC分子。其结构包括BCL6 ligand-2 作为PROTAC靶蛋白配体，E3 泛素连接酶配体 Thalidomide-4-OH，以及连接这两者的 PROTAC Linker。E3 泛素连接酶配体和 Linker 结合形成的化学结构为 2-(2,6-Dioxopiperidin-3-yl)-4-((2-(2-hydroxyethoxy)ethyl)amino)isoindoline-1,3-dione。

15:0 PG sodium 是线粒体和微粒体膜中的阴离子磷脂，作为蛋白激酶 C 家族的激活剂，对肺表面活性剂组成尤其是肺部层状体膜内起着关键角色。

(Rac)-Idroxioleic acid sodium [又称2-Hydroxyoleic acid sodium] 是一类由油酸 (OA) 衍生的化合物，通过与细胞质膜结合，能够改变脂质的组成。此外，该化合物还展现出了抗肿瘤的潜力。

Decamethylene glycol is a substance used as a reagent in the biological study of modified oligonucleotide with in vivo antitumoral activity. Also used in the pharmaceutical study on the composition of essential oils obtained from myrrh and frankincense an