chaetoglobosin a

Chaetoglobosin A, the active compound extracted of Penicillium aquamarinium, is a member of the cytochalasan family. It preferentially induces apoptosis.

chaetoglobosin Vb 是一种从内生球藻中分离出来的新型细胞松弛素生物碱。

Chaetoglobosin C (Compound 4)，源自真菌Chaetomium globosum KMITL-N0802，为一种蒽醌-色酮类化合物，具备抗结核分枝杆菌的活性。

Chaetoglobosin Fex 来自海洋源性内生真菌的 Chaetoglobosin Fex 通过巨噬细胞中的 Toll 样受体 4 信号传导抑制炎症介质的诱导。

19-O-Acetylchaetoglobosin A is a fungal metabolite originally isolated fromC. globosumthat has actin polymerization inhibitory and cytotoxic activities.1,2It inhibits actin polymerization in a cell-free assay when used at a concentration of 2 μM.219-O-Acetylchaetoglobosin A (3.2, 10, and 32 μg ml) is cytotoxic to HeLa cervical cancer cells.1 1.Umeda, M., Ohtsubo, K., Saito, M., et al.Cytotoxicity of new cytochalasans from Chaetomium globosumExperientia31(4)435-438(1975) 2.Sekita, S., Yoshihira, K., Natori, S., et al.Structure-activity relationship of thirty-nine cytochalasans observed in the effects on cellular structures and cellular events and on actin polymerization in vitroJ. Pharmacobiodyn.8(11)906-916(1985)