c-12-200

C12-200是一个基准的可离子化的阳离子类脂质与辅助类脂质一起，用于 mRNA 的传递。

(S)-C12-200 是 C12-200 的 (S)-异构体，一种可电离的阳离子脂质和辅助脂质，用于构建脂质纳米颗粒及 mRNA 递送。

4’-hydroxy Trazodone is a metabolite of the antidepressant and sedative trazodone.1It is an inhibitor of organic anion transporter 3 (OAT3; Ki= 16.9 μM) and is selective for OAT3 over OAT1 (Ki= >200 μM).2 1.Yamato, C., Takahashi, T., Fujita, T., et al.Studies on metabolism of trazodone, II. Metabolic fate after intravenous administration and effects on liver microsomal drug-metabolizing enzymes in ratsXenobiotica4(12)765-777(1974) 2.Zou, L., Matsson, P., Stecula, A., et al.Drug metabolites potently inhibit renal organic anion transporters, OAT1 and OAT3J. Pharm. Sci.110(1)347-353(2021)