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22

抑制剂 & 化合物

8

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T9597	H2S Donor 5a N-(苯甲酰基硫基)苯甲酰胺	Endogenous Metabolite	Metabolism
	H2S Donor 5a 是一种稳定的、半胱氨酸活化的的 H2S 供体。它是研究 H2S 的有用工具。
T4177	U 19963	Others	Others
	U 19963 是几种酶和受体的强效抑制剂，已被用于研究药物对生物系统的影响，它被发现具有广泛的生物活性，包括抗炎、抗肿瘤和抗菌特性。
T4630	NSC 404988	Others	Others
	NSC 404988 是一种苯甲酰胺类生物活性化合物，用于化合物的合成和药物的制备，还被用于药物代谢的研究和生物系统中代谢物的分析。
T22739	DMPO 5,5-二甲基-1-吡咯啉-N-氧化物,5,5-Dimethyl-1-pyrroline N-oxide	Others	Others
	DMPO (5,5-Dimethyl-1-pyrroline N-oxide) 是一种细胞渗透性亲水自旋诱捕剂，可用于超氧化物检测。
T3647	HTHQ HX 1171,HTHQ(1-O-Hexyl-2,3,5-trimethylhydroquinone),1-O-hexyl-2,3,5-trimethylhydroquinone	Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB
	HTHQ (HTHQ(1-O-Hexyl-2,3,5-trimethylhydroquinone)) 是一种强力的亲脂性酚类抗氧化剂。它通过与活性氧直接反应，清除 ROS，从而形成更稳定的自由基，具有很强的抗氧化活性。
T14922	Cefodizime	Antibacterial; Antibiotic	Microbiology/Virology
	Cefodizime 是一种新型头孢菌素抗生素，具有广泛的生物活性。Cefodizime 对肾脏没有毒性且具有良好的耐受性和免疫调节活性，具有抗菌活性，可用于研究呼吸系统和泌尿系统的严重感染。
T22794	G36 G-36	Estrogen Receptor/ERR	Endocrinology/Hormones
	G36是一种细胞可渗透的G 蛋白偶联雌激素受体(GPER/GPR30)的非甾体拮抗剂。G36抑制17β-雌二醇或GPER 选择性激动剂G-1的激活（IC50分别为112和165 nM）。G36对ERα或ERβ均无可检测的结合活性。G36通过GPER 阻断由雌激素触发的PI3K 的激活或钙动员，并且它通过雌激素或G-1而不是通过EGF 抑制ERK 的激活。
T19001	Heptamethine cyanine dye-1 ADS 815EI	Others	Others
	Heptamethine cyanine dye-1, a near-infrared cyanine dye, is used for fluorescence imaging in biological systems.
T19313	Erythropterin	Others	Others
	Erythropterin is a Pterin derivative that belongs in a group of heterocyclic compounds that are frequently found in biological systems.
T26447	A 78773 A78773,A-78773
	A 78773 is a potent, selective, direct, and reversible 5-lipoxygenase inhibitor. It has activity in a variety of purified cells and in more complex biological systems such as whole blood, lung fragments, and tracheal tissues. A 78773 acts against inflamma
T39754	HKPerox-2
	HKPerox-2 is an excellently selective and sensitive green fluorescent probe toward H 2 O 2 over 30-fold other tested ROS/RNS in chemical and biological systems. HKPerox-2 is a O-methyl rhodol derivative and specifically recognize H 2 O 2 based on a tandem payne/dakin reaction.
T18061	KB02-SLF	Others; PROTACs	Others; PROTAC
	KB02-SLF is a PROTAC-based nuclear FKBP12 degrader, known as a molecular glue. It facilitates the degradation of nuclear FKBP12 by covalently modifying DCAF16, an E3 ligase. Moreover, KB02-SLF enhances the longevity of protein degradation in biological systems. The compound SLF acts as a linker, binding to the ubiquitin E3 ligase ligand KB02, resulting in the formation of KB02-SLF[1].
T36603	(±)5-HEPE
	(±)5-HEPE is produced by non-enzymatic oxidation of EPA. It contains equal amounts of 5(S)-HEPE and 5(R)-HEPE. The biological activity of (±)5-HEPE is likely mediated by one of the individual isomers, most commonly the 5(S) isomer in mammalian systems. EPA can be metabolized to 5-HEPE in human and bovine neutrophils, and human eosinophils, which is further metabolized to 5-oxoEPE and LTB5. The 5-series metabolites of EPA, namely 5-HEPE, 5-oxoEPE, and LTB5, have significantly decreased biological...
T18060	KB02-JQ1	Others; PROTACs	Others; PROTAC
	KB02-JQ1 is a potent and specific proteolysis targeting chimera (PROTAC) that specifically degrades BRD4, acting as a molecular glue. It does not degrade BRD2 or BRD3. The mechanism of action involves covalent modification of the E3 ligase DCAF16, thereby promoting BRD4 degradation. Importantly, KB02-JQ1 demonstrates enhanced stability and durability in facilitating protein degradation within biological systems. The compound forms a complex with the ubiquitin E3 ligase ligand KB02 through a link...
T35506	(±)12-HEPE
	(±)12-HEPE is produced by non-enzymatic oxidation of EPA. It contains equal amounts of 12(S)-HEPE and 12(R)-HEPE. The biological activity of (±)12-HEPE is likely mediated by one of the individual isomers, most commonly the 12(S) isomer in mammalian systems. 12-HEPE inhibits platelet aggregation with the same potency as 12-HETE, exhibiting IC50 values of 24 and 25 &#181M, respectively. [1] These compounds are also equipotent as inhibitors of U46619-induced contraction of rat aorta (IC50s = 8.6-8....
T76167	Carboxypeptidase A
	Carboxypeptidase A(EC 3.4.2.1) 是一种含锌的金属蛋白酶，常用于生化研究。Carboxypeptidase A 催化与多肽链 C 端相邻的肽键的水解。Carboxypeptidase A 是典型的金属蛋白酶，在生物系统中发挥重要作用。
T36501	CYPMPO RR 071
	CYPMPO is a free radical spin trap with excellent trapping capabilities toward hydroxyl and superoxide radicals in biological and chemical systems. Decay of the superoxide adduct of CYPMPO proceeds in an apparent first order fashion with half-lives of 15 and 51 minutes in a UV-illuminated hydrogen peroxide solution and a hypoxanthine/xanthine oxidase system, respectively. CYPMPO traps superoxide radicals generated by bovine neutrophils as effectively as DEPMPO.[1] The high melting point (126°C),...
T36173	L-Glutathione, oxidized (sodium salt)
	Glutathione can occur in reduced (GSH), oxidized (GSSG), or in mixed disulfide forms and is ubiquitous in multiple biological systems serving as the major thiol-disulfide redox buffer of the cell. GSSG is the oxidized form of GSH . It can be reduced back to GSH through the NADPH-dependent enzyme glutathione reductase. GSSG functions as a hydrogen acceptor in the enzymatic determination of NADP+ and NADPH and can be a proximal donor in S-glutathionylation post translational modifications. The rat...
T38117	WSP-5 Washington State Probe-5,WSP-5
	Hydrogen sulfide (H2S) is an important gaseous mediator, like nitric oxide, that has significant effects on the immunological, neurological, cardiovascular and pulmonary systems of mammals. WSP-5 is a reactive disulfide-containing, fluorescent probe designed for fast detection of H2S in biological samples and cells. Through a reaction-based fluorescent turn-on strategy, WSP-5 selectively and rapidly reacts with H2S, generating a fluorophore with excitation and emission maxima of 502 and 525 nm, ...
T38075	ThioFluor 623
	The rapid, selective, and sensitive sensing of thiols is important in diverse areas of research. This thiofluor 623 responds upon exposure to thiols with an increase in fluorescence intensity of up to 120-fold. The response is selective for thiols and occurs in aqueous media. In the absence of thiols, the probe is essentially non-fluorescent; thiols cause cleavage of the probe, generating a fluorophore with an absorption maximum of 563 nm and emission at 623 nm. The fluorescence quantum yield of...
T36027	DEPMPO-biotin
	DEPMPO is a nitrone that is used to spin trap reactive O-, N-, S-, and C-centered radicals and allow their characterization when used in association with electron spin resonance. It is noted for the stability of adducts formed. DEPMPO can be used in vitro or in vivo, as it crosses lipid bilayer membranes and is a good trapping agent in biological systems. DEPMPO-biotin is a biotinylated form of DEPMPO which retains the outstanding persistency of its adducts. The biotin moiety offers an effective...
T35639	Sulfatides (bovine) (sodium salt)
	Sulfatides are endogenous sulfoglycolipids with various biological activities in the central and peripheral nervous systems, pancreas, and immune system. They are produced from the combination of ceramide and UDP-galactose in the endoplasmic reticulum followed by sulfation in the Golgi apparatus. The ceramide portion contains variable fatty acid chain lengths, which are tissue- and pathology-dependent. Sulfatides are primarily found in the myelin sheath of oligodendrocytes and Schwann cells, wit...

化合物

Cat.No: T9597

Synonym: N-(苯甲酰基硫基)苯甲酰胺

Target: Endogenous Metabolite

Cat.No: T4177

Target: Others

Cat.No: T4630

Target: Others

Cat.No: T22739

Synonym: 5,5-二甲基-1-吡咯啉-N-氧化物,5,5-Dimethyl-1-pyrroline N-oxide

Target: Others

Cat.No: T3647

Synonym: HX 1171,HTHQ(1-O-Hexyl-2,3,5-trimethylhydroquinone),1-O-hexyl-2,3,5-trimethylhydroquinone

Target: Reactive Oxygen Species

Cat.No: T14922

Target: Antibacterial, Antibiotic

Cat.No: T22794

Synonym: G-36

Target: Estrogen Receptor/ERR

Heptamethine cyanine dye-1

Cat.No: T19001

Synonym: ADS 815EI

Target: Others

Cat.No: T19313

Target: Others

Cat.No: T26447

Synonym: A78773,A-78773

Cat.No: T39754

Cat.No: T18061

Target: Others, PROTACs

Cat.No: T36603

Cat.No: T18060

Target: Others, PROTACs

Cat.No: T35506

Carboxypeptidase A

Cat.No: T76167

Cat.No: T36501

Synonym: RR 071

L-Glutathione, oxidized (sodium salt)

Cat.No: T36173

Cat.No: T38117

Synonym: Washington State Probe-5,WSP-5

Cat.No: T38075

Cat.No: T36027

Sulfatides (bovine) (sodium salt)

Cat.No: T35639

Cat. No.	Product Name	Target	Signaling Pathways
T2778	(+)-Catechin Hydrate 一水合儿茶素,(+)-水合儿茶素	Antioxidant; COX	Immunology/Inflammation; Neuroscience; oxidation-reduction
	(+)-Catechin hydrate 是来自茶树的抗氧化类黄酮，可抑制环加氧酶-1，IC50为 1.4 μM。它是一种自由基清除剂，可防止多种生物系统中自由基介导的损害。
T19262	D-Glucose 6-phosphate disodium salt D-Glucose 6-phosphate disodium salt	Endogenous Metabolite	Metabolism
	D-Glucose 6-phosphate disodium salt 广泛存在于生物提内的化合物，是葡萄糖第 6 号碳经过磷酸化后生成的分子，参与磷酸戊糖途径与糖酵解途径等体内多种多种代谢调节途径。
T4874	Thiamine pyrophosphate Cocarboxylase,焦磷酸硫胺素,Aneurinepyrophosphoric acid,Thiamine pyrophosphate chloride	Endogenous Metabolite	Metabolism
	Thiamine pyrophosphate (Cocarboxylase) 是维生素 B1 的辅酶形式，是丙酮酸脱氢酶复合物和酮戊二酸脱氢酶复合物的必需中间体，能够用于研究评估生物系统中的脱羧机制。
T7971	8-Amino-1-Naphthalenesulfonic Acid	Others	Others
	8-Amino-1-Naphthalenesulfonic Acid 是萘的衍生物，用作荧光染料和有机合成中的试剂。它是一种具有高Stokes 位移的高荧光化合物，使其成为广泛生物系统的理想荧光标记。
T10662L	Calcimycin Antibiotic A-23187,离子载体(钙镁盐混合物),A-23187	Apoptosis; Antibacterial; Antibiotic; Autophagy; Antifungal	Apoptosis; Autophagy; Microbiology/Virology
	Calcimycin (A-23187) 是抗生素和二价阳离子离子载体。它抑制革兰氏阳性细菌和一些真菌生长，也抑制 ATP 酶的活性并解耦哺乳动物细胞的氧化磷酸化。它通过增加细胞内钙浓度诱导 Ca2+依赖性细胞死亡。
T5083	L-Cysteic acid monohydrate L-磺基丙氨酸一水合物,3-Sulfo-L-alanine Monohydrate	Endogenous Metabolite; GluR	Metabolism; Neuroscience
	L-Cysteic acid monohydrate (3-Sulfo-L-alanine Monohydrate) 是内源性代谢产物的一种。
TN1821	Kaempferol 3-O-arabinoside 山奈酚-3-O-α-L-吡喃阿拉伯糖苷,堪非醇 3-O-阿拉伯糖苷	ROS; Antifection	Immunology/Inflammation; Microbiology/Virology
	Kaempferol-3-O-α±-D-arabinoside displays cytotoxic and high antioxidant activity.Kaempferol-3-O-arabinoside and kaempferol-3-O-glucoside can function as antioxidants in biological systems, particularly skin exposed to UV radiation by scavenging ROS, and protect cellular membrane against ROS; they can be applicable to new cosmeceuticals for antioxidant, antiaging, and antibacterial activity.
T37974	(S)-Coriolic acid 13(S)-HODE	Lipoxygenase; Mitochondrial Metabolism; PPAR	DNA Damage/DNA Repair; Metabolism
	(S)-Coriolic acid (13(S)-HODE) 是一种重要的细胞内信号剂，是亚油酸与植物和哺乳动物脂氧合酶反应生成的，在各种生物系统中参与细胞增殖和分化。(S)-Coriolic acid 在 1 μM 左右时，它能抑制肿瘤细胞与血管内皮的粘附，能下调 IRGpIIb/IIIa 受体的表达。(S)-Coriolic acid 是15-脂氧合酶 (15-LOX) 代谢产物，常作为内源性配体激活 PPARγ。(S)-Coriolic acid 诱导线粒体功能障碍和气道上皮损伤。

天然产物

(+)-Catechin Hydrate

Cat.No: T2778

Synonym: 一水合儿茶素,(+)-水合儿茶素

Target: Antioxidant, COX

D-Glucose 6-phosphate disodium salt

Cat.No: T19262

Synonym: D-Glucose 6-phosphate disodium salt

Target: Endogenous Metabolite

Thiamine pyrophosphate

Cat.No: T4874

Synonym: Cocarboxylase,焦磷酸硫胺素,Aneurinepyrophosphoric acid,Thiamine pyrophosphate chloride

Target: Endogenous Metabolite

8-Amino-1-Naphthalenesulfonic Acid

Cat.No: T7971

Target: Others

Cat.No: T10662L

Synonym: Antibiotic A-23187,离子载体(钙镁盐混合物),A-23187

Target: Apoptosis, Antibacterial, Antibiotic, Autophagy, Antifungal

L-Cysteic acid monohydrate

Cat.No: T5083

Synonym: L-磺基丙氨酸一水合物,3-Sulfo-L-alanine Monohydrate

Target: Endogenous Metabolite, GluR

Kaempferol 3-O-arabinoside

Cat.No: TN1821

Synonym: 山奈酚-3-O-α-L-吡喃阿拉伯糖苷,堪非醇 3-O-阿拉伯糖苷

Target: ROS, Antifection

(S)-Coriolic acid

Cat.No: T37974

Synonym: 13(S)-HODE

Target: Lipoxygenase, Mitochondrial Metabolism, PPAR

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