biie-0246

BIIE-0246是一种选择性的NPY2R拮抗剂，对大鼠[125I]PYY3-36位点的IC50=15 nM，能够在NPY刺激下降低 p-AKT S473、P-p44/42 MAPK 的表达。

Demexiptiline is a tricyclic antidepressant used in France for the treatment of depression. It acts primarily as a norepinephrine reuptake inhibitor similarly to desipramine.

BIIE-0246 is a potent, selective and competitive non-peptide antagonist for the neuropeptide Y Y2 receptor. BIIE-0246 displays > 650-fold selectivity over Y1, Y4 and Y5 receptors.

Potent, selective and competitive nonpeptide antagonist for the neuropeptide Y Y2 receptor (IC50 = 15 nM). Displays > 650-fold selectivity for NPY Y2 over Y1, Y4 and Y5 receptors. Active in vivo.