ad 2

CRANAD 2 是一种特异性近红外 (NIR) 荧光探针，可用于检测 Aβ 斑块。它可透过血脑屏障，且对 Aβ 聚集体有高亲和性，其 Kd=38 nM。

Selective, high affinity 5-HT1A receptor antagonist

AD 20 is designed to reduce toxicity. It also enhances the activity of anticancer drugs.

Rad 243 is a sodium channel blocker with antiarrhythmic activity.

AD 2239 is a bioactive chemical.

Rad 242 is a hydrophobic lidocaine derivative.

STAD-2 is a cell permeable akap disruptor, selectively binding to pka-rii and blocking the interaction of pka-ri with akap

AKAP disruptor. Selectively binds PKA-RI with high affinity (KD values are 6.2 and 12.1 nM for the RIα and β subunits, respectively) and blocks its interaction with AKAP. Inhibits type I PKA-mediated phosphorylation in live cells. Cell permeable.

AD-2646 具有抗抑郁活性，抑制2-脱氧-D-葡萄糖（2-DG）诱导的胃酸分泌。

AD-2646 FA 具有抗抑郁活性，抑制2-脱氧-D-葡萄糖（2-DG）诱导的胃酸分泌。

Trimipramine maleate (Surmontil maleate) 是一种 5-HT 受体拮抗剂，对 5-HT1C、5-HT2和 5-HT1A 受体的 pKi 值分别为 6.39、8.10和 4.66。

Trimethylamine N-oxide dihydrate (TMANO Dihydrate) 是内源性代谢产物的一种。

3-methyl-1,2-dihydroquinolin-2-one 是一个已知的 ATAD2 溴结构域的微摩尔抑制剂。

2-Aminopurine-9-beta-D-(2’-deoxy)riboside 是2-Aminopurine 的衍生物。

TT-OAD2 free base has the potential for diabetes treatment. TT-OAD2 free base is a non-peptide glucagon-like peptide-1 (GLP-1) receptor agonist with an EC50 of 5 nM.

TT-OAD2 is a non-peptide agonist of the glucagon-like peptide-1 (GLP-1) receptor (EC50: 5 nM), with potential for diabetes treatment.

BAY-850 是一种具有选择性和有效的三磷酸腺苷酶家族蛋白 2 (ATAD2) 抑制剂，（IC50 ： 166 nM） ，在体外和体内模型中抑制卵巢癌的生长和转移。

Streptonigrin is a natural product produced by Streptomyces flocculus, has both anti-tumor and anti-bacterial activity. Streptonigrin acts as a pan-PAD inhibitor (IC50s: 48.3±34.2 µM, 26.1±0.3 µM, 0.43±0.03 µM, and 2.5±0.4 µM for PAD1, PAD2, PAD3, and PAD

CAD204520 作为一种SERCA抑制剂（IC50 = 0.34 μM），针对带有野生型NOTCH1突变的T细胞急性淋巴细胞白血病（T-ALL）和边缘区细胞淋巴瘤（MCL）。

PAD2-IN-2 (cis-isomer of 1) TFA 为蛋白质精氨酸脱亚胺酶 2 (PAD2) 的抑制剂，拥有偶氮苯光开关，可光学调控 PAD 活性。PAD2-IN-2 TFA 能抑制组蛋白 H3-瓜氨酸化。

Deuterated ivermectin B1a

Crisdesalazine (AAD 2004) 是微粒体前列腺素 E2 合酶 1 (mPGES-1) 的抑制剂。 Crisdesalazine 可减少自噬体形成、轴索病变和运动神经元变性，改善运动功能并延长寿命。

CRANAD-28 是一种血脑屏障（BBB）穿透型双光子成像探头，能够显示淀粉样蛋白斑块，可以标记斑块和脑淀粉样血管病。

PAD2-IN-1, a benzimidazole-based derivative, is an efficacious and specific inhibitor of protein arginine deiminase 2 (PAD2). Demonstrating remarkable selectivity, PAD2-IN-1 exhibits a 95-fold higher affinity for PAD2 in comparison to PAD4 and a 79-fold higher affinity than PAD3.