VZ185

VZ185 is an effective and selective dual BRD7 9 PROTAC degrader (DC50s: 4.5 and 1.8 nM, respectively).

cis-VZ 185 is a negative control for VZ 185.

BRD7-IN-1 free base, a modified derivative of BI7273 (BRD7 9 inhibitor), interacts with a VHL ligand through a linker, constituting the PROTAC VZ185 (targeting BRD7 9 with DC50 values of 4.5 and 1.8 nM, respectively)[1].

BRD7-IN-1 是一种修饰的 BI7273 衍生物 (BRD7 9 抑制剂)。BRD7-IN-1 通过与 VHL 配体连接形成 PROTAC VZ185。VZ185 抑制 BRD7 9 的 DC50分别是 4.5 nM 和1.8 nM。