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7

抑制剂 & 化合物

1

TargetMol 试剂盒

5

重组蛋白

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Cat. No.	Product Name	Form	Specificity Of Inhibition
C0002	Phosphatase Inhibitor Cocktail I (100× ddH2O) 磷酸酶抑制剂 Cocktail I (100× ddH2O)	Solution (100× in ddH2O)	Acid Phosphatase, Alkaline phosphatase, <em>PTPs</em>, ATPases

TargetMol 试剂盒

磷酸酶抑制剂 Cocktail I (100× ddH2O)

Cat.No: C0002

Cat. No.	Product Name	Target	Signaling Pathways
T31458	DiFMUP 6,8-Difluoro-4-methylumbelliferyl phosphate
	DiFMUP (6,8-Difluoro-4-methylumbelliferyl phosphate) 是一种荧光底物，抑制蛋白酪氨酸磷酸酶（PTPs），可用于检测苏氨酸磷酸酶的活性。
T36367	RK-682 (calcium salt)
	Protein tyrosine phosphatases (PTPs) remove phosphate from tyrosine residues of cellular proteins. Reversible phosphorylation catalyzed by the coordinated actions of protein tyrosine kinases and phosphatases is key to the regulation of the signaling events that control cell growth and proliferation, differentiation, and survival or apoptosis, as well as adhesion and motility. RK-682, a bioactive compound originally isolated from the fermentation of Streptomyces sp. 88-682, is an inhibitor of the...
T40846	3,5-Difluoro-L-tyrosine
	3,5-Difluoro-L-tyrosine is a functional and tyrosinase-resistant mimic of tyrosine, commonly utilized for evaluating the substrate specificity of protein tyrosine phosphatases (PTPs).
T40968	MLS-0437605
	MLS-0437605 is a potent and selective inhibitor of dual-specificity phosphatase 3 (DUSP3), with an IC50 of 3.7 μM. It exhibits higher selectivity towards DUSP3 in comparison to DUSP22 and other protein tyrosine phosphatases (PTPs).
T38834	LYP-IN-1
	LYP-IN-1 is a powerful LYP inhibitor that demonstrates high potency, selectivity, and specificity, with a Ki of 110 nM and an IC 50 of 0.259 μM. Beyond its primary target, LYP-IN-1 also exhibits selectivity towards a wide range of PTPs, including SHP1 (IC 50 = 5 μM) and SHP2 (IC 50 = 2.5 μM). Additionally, LYP-IN-1 demonstrates remarkable efficacy in T- and mast cells, making it a valuable tool for investigating autoimmune disorders.
T63405	NAZ2329
	NAZ2329 是受体型蛋白质酪氨酸磷酸酶 (RPTPs) R5 亚家族的一个细胞可渗透抑制剂，与其他 PTPs 相比，其变构且能够优先抑制 PTPRZ (hPTPRZ1 的IC50= 7.5 μM) 和PTPRG (hPTPRGIC50= 4.8 μM)。NAZ2329 能够与PTPRZ 的 D1结构域结合，与PTPRZ 整个 (D1 + D2) 片段相比，其能够更有效地抑制 PTPRZ1-D1片段 (IC50: 1.1 μM)。NAZ2329 能够抑制胶质母细胞瘤细胞的肿瘤生长，并表现出抑制干细胞样特性。
T80544	PTPσ Inhibitor, ISP	Phosphatase	Metabolism
	PTPσ Inhibitor, ISP 结合并抑制重组人PTPσ的信号传导，具有穿透细胞膜的能力，有助于缓解CSPG介导的脊髓损伤模型中轴突的生长抑制。该抑制剂能增强LPC引起的脊髓脱髓鞘损伤的髓鞘再生，并在MS动物模型中促进OPC的迁移、分化、髓鞘形成及功能恢复。

化合物

Cat.No: T31458

Synonym: 6,8-Difluoro-4-methylumbelliferyl phosphate

RK-682 (calcium salt)

Cat.No: T36367

3,5-Difluoro-L-tyrosine

Cat.No: T40846

Cat.No: T40968

Cat.No: T38834

Cat.No: T63405

PTPσ Inhibitor, ISP

Cat.No: T80544

Target: Phosphatase

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-03452	PTS Protein, Human, Recombinant (His) PTPS,PTS,6-pyruvoyltetrahydropterin synthase	Human	E. coli
	PTS(6-pyruvoyltetrahydropterin synthase) belongs to the PTPS family. It catalyzes the elimination of inorganic triphosphate from dihydroneopterin triphosphate, which is the second and irreversible step in the biosynthesis of tetrahydrobiopterin from GTP. Tetrahydrobiopterin, also known as BH(4), is an essential cofactor and regulator of various enzyme activities, including enzymes involved in serotonin biosynthesis and NO synthase activity. Mutations in this gene result in hyperphenylalaninemia....
TMPY-04125	PTP1B Protein, Human, Recombinant (His) protein tyrosine phosphatase, non-receptor type 1,PTP1B,PTPN...	Human	E. coli
	PTP1B, also known as PTPN1, belongs to the protein-tyrosine phosphatase (PTP) family. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. PTP1B contains 1 tyrosine-protein p...
TMPY-02763	DEP-1 Protein, Human, Recombinant (aa 997-1337, His) HPTPeta,SCC1,protein tyrosine phosphatase, receptor type, J,...	Human	E. coli
	DEP1 / PTPRJ (Receptor-type tyrosine-protein phosphatase eta) is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes, including cell growth, differentiation, mitotic cycle, and oncogenic transformation. DEP1 / PTPRJ possesses an extracellular region containing five fibronectin type III repeats, a single transmembrane region, and a single intracytoplasmic catalytic domain, and thus represents a receptor-...
TMPY-03125	SHP-2 Protein, Mouse, Recombinant (His) SAP-2,Syp,PTP1D,SH-PTP2,SH-PTP3,SHP-2,PTP2C,2700084A17Rik,AW...	Mouse	HEK293 Cells
	SHP2, also known as PTPN11, belongs to the protein-tyrosine phosphatase(PTP) family, non-receptor class 2 subfamily. PTPs catalyze the removal of phosphate groups from tyrosine residues by the hydrolysis of phosphoric acid monoesters. They dephosphorylate EGFR, JAK2 and TYK2 kinases, promoting oncogenic transformation. SHP2 is widely expressed, with highest levels in heart, brain, and skeletal muscle. SHP2 acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participat...
TMPY-03296	SHP-1 Protein, Mouse, Recombinant (aa 207-597, His & GST) SH-PTP1,Hcph,70Z-SHP,Ptp1C,protein tyrosine phosphatase, non...	Mouse	Baculovirus Insect Cells
	PTPN6 is an enzyme that belongs to the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of PTPN6 contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of PTPN6 with its substrates. PTPN6 is expressed primarily in hematopoietic cells, and functions as an ...

重组蛋白

PTS Protein, Human, Recombinant (His)

Cat.No: TMPY-03452

Species: Human

Expression System: E. coli

PTP1B Protein, Human, Recombinant (His)

Cat.No: TMPY-04125

Species: Human

Expression System: E. coli

DEP-1 Protein, Human, Recombinant (aa 997-1337, His)

Cat.No: TMPY-02763

Species: Human

Expression System: E. coli

SHP-2 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-03125

Species: Mouse

Expression System: HEK293 Cells

SHP-1 Protein, Mouse, Recombinant (aa 207-597, His & GST)

Cat.No: TMPY-03296

Species: Mouse

Expression System: Baculovirus Insect Cells

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