Cat. No. | Product Name | Target | Signaling Pathways |
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T11939 |
MAGL-IN-1
|
Lipase | Metabolism |
MAGL-IN-1 is a selective and potent monoacylglycerol lipase (MAGL) inhibitor with an IC50 of 80 nM. | |||
T61198 | FAAH/MAGL-IN-1 | ||
FAAH/MAGL-IN-1, also known as compound SIH 3, is a highly effective inhibitor of FAAH (fatty acid amide hydrolase) and MAGL (monoacylglycerol lipase). It exhibits IC50 values of 31 nM and 29 nM against FAAH and MAGL, respectively. This compound shows promising potential for advancing research in the field of neuropathic pain [1]. | |||
T81880 | MAGL-IN-11 | MAGL | Metabolism |
MAGL-IN-11(化合物 29),一种选择性且可逆的MAGL抑制剂,具备研究炎症、癌症和抗氧化潜力。 | |||
T81879 | MAGL-IN-8 | MAGL | Metabolism |
MAGL-IN-8 (compound 13) 是一种针对 hMAGL 的高选择性可逆抑制剂,其IC50值为2.5 ± 0.4 nM。 | |||
T81881 | MAGL-IN-10 | MAGL | Metabolism |
MAGL-IN-10为一种可逆MAGL抑制剂,展现出优良的ADME特性且体内毒性低。该化合物适用于癌症、神经系统疾病和炎症病理学研究。 | |||
T81878 | MAGL-IN-9 | MAGL | Metabolism |
MAGL-IN-9 (compound 16)为高选择性、可逆MAGL抑制剂,其IC50值为2.7 nM[1]< /sup >。 | |||
T61707 |
FAAH/MAGL-IN-2
|
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FAAH/MAGL-IN-2 是一种有效的,可逆的,具有口服活性且可透过血脑屏障的 FAAH 和 MAGL 抑制剂,其IC50值分别为 11 nM 和 36 nM (b>Ki 值分别为 28 nM 和 60 nM)。FAAH/MAGL-IN-2 有研究神经性疼痛的潜力而不引起运动障碍。 | |||
T37374 |
URB754
|
||
URB754 is a potent and noncompetitive inhibitor of monoacylglycerol lipase (MAGL), exhibiting an IC50 value of 200 nM for the recombinant rat brain enzyme. However, it does not inhibit human recombinant, rat brain, or mouse brain MAGL at concentrations up to 100 μM. There is evidence that the MAGL inhibitory activity of URB754 may be attributed to the impurity bis(methylthio)mercurane (IC50 = 11.9 nM for rat recombinant MAGL) that is found in commercial preparations. URB754 inhibits rat brain fa... | |||
T28235 |
OMDM169
OMDM 169,OMDM-169 |
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OMDM169 is a potent and selective MAGL inhibitor. OMDM169 could enhances 2-AG levels and of exerts analgesic activity via indirect activation of cannabinoid receptors. OMDM169 exhibited 0.13 microM<IC(50)<0.41 microM towards 2-AG hydrolysing activities in | |||
T36498 |
CAY10762
CAY10762 |
||
CAY10762 is an inhibitor of monoacylglycerol lipase (MAGL; IC50= 34.1 nM).1It reduces hydrogen peroxide-induced lactate dehydrogenase (LDH) release from Neuro2a cells when used at a concentration of 1 μM. CAY10762 (10 mg/kg) increases levels of 2-arachidonoyl glycerol in mouse brain. 1.Castelli, R., Scalvini, L., Vacondio, F., et al.Benzisothiazolinone derivatives as potent allosteric monoacylglycerol lipase inhibitors that functionally mimic sulfenylation of regulatory cysteinesJ. Med. Chem.63(... |