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Targets Recommended: Others

16

抑制剂 & 化合物

1

重组蛋白

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Cat. No. Product Name Target Signaling Pathways
T27628 IS-159

IS 159,IS159

Others Others
IS-159, a 5-HT1D agonist, is used potentially for the treatment of migraine.
T5100 DJ-V-159

DJ-V159

GPR; Androgen Receptor Endocrinology/Hormones; GPCR/G Protein
DJ-V-159 (DJ-V159) 是一种G 蛋白偶联受体家族C 组6 A 的激动剂。
T4043 ETC-159

ETC159,ETC-1922159,ETC 159

Wnt/beta-catenin; Porcupine Cytoskeletal Signaling; Stem Cells
ETC-159 (ETC-1922159) 是一种具有口服活性的,有效 PORCN 抑制剂。抑制β-catenin 报告基因活性的 IC50值为2.9 nM。
T29034 U75302

U 75302,U-75302

Others Others
U75302 is an antagonist of thymosin beta-4 (TB4) receptor with a Ki value of 159 nM on guinea pig lung membranes.
T11309 FMF-04-159-2

CDK Cell Cycle/Checkpoint
FMF-04-159-2 inhibits CDK14 and CDK2 with IC50s of 39.6 nM and 256 nM in NanoBRET assay, respectively. FMF-04-159-2 is a covalent CDK14 inhibitor.
T79774 Antibacterial agent 159

Antibiotic Microbiology/Virology
Antibacterialagent 159 (Compound 6d) 是一款高效抗菌化合物,具备针对脓疱疮和C. difficile感染(CDI)的抗菌活性。其使用过程中未发现C. difficile复发现象,并对益生肠道菌群仅有微弱影响。
T15021 CV-159

Others Others
CV-159 is a unique dihydropyridine Ca2+ antagonist with antiinflammatory activities. It has an anti-calmodulin (CaM) action.
T80099 Ovalbumin (154-159)

Angiotensin-converting Enzyme (ACE) Metabolism
Ovalbumin (154-159)为卵清蛋白片段,同时作为一种有效的血管紧张素转换酶 (ACE) 抑制剂,适用于高血压研究。
T62894 AZ-PFKFB3-67 quarterhydrate

Others Others
AZ-PFKFB3-67 quarterhydrate 是一种选择性的、高效的代谢激酶 PFKFB3 激酶抑制剂,作用于 PFKFB3 (IC50: 11 nM)、PFKFB2 (IC50: 159 nM) 和 PFKFB1 (IC50: 1130 nM)。
T32337 JWH-167

JWH 167,JWH167

Others Others
JWH 167, a synthetic cannabinoid (CB), has moderate affinities for central CB1 (Ki = 90 nM) and peripheral CB2 (Ki = 159 nM) receptors. Its physiological and toxicological properties have not been evaluated. This product is only applied for forensic and r
T13743 JH-XI-10-02

EGFR; PROTACs Angiogenesis; JAK/STAT signaling; PROTAC; Tyrosine Kinase/Adaptors
JH-XI-10-02 causes proteasomal degradation, does not affect CDK8 mRNA levels. JH-XI-10-02 shows no effect on CDK19. JH-XI-10-02 is a potent and selective degrader of CDK8, with an IC50 of 159 nM, based on PROTAC.
T39815 anti-TNBC agent-1

Others Others
anti-TNBC agent-1 is a highly effective compound specifically designed to target and combat triple-negative breast cancer (TNBC). It demonstrates remarkable potency against various breast cancer cell types, with IC50 values spanning from 0.20 μM to 0.27 μM. The mechanism of action of anti-TNBC agent-1 involves inducing apoptosis in SUM-159 cells through the mitochondria pathway, as well as causing G1 phase arrest in these cells.
T35671 Salazinic Acid

Others Others
Salazinic acid is a depsidone lichen metabolite that has been found in P. sulcata.1 It is active against B. cereus, B. subtilis, S. aureus, P. aeruginosa, S. typhimurium, C. albicans, and A. niger in vitro (MICs = 3.9-30.8 mM). Salazinic acid is cytotoxic to MM98, A431, and HaCaT cells in crystal violet (EC50s = 159, 2,870, and 48 μM, respectively) and neutral red uptake assays (EC50s = 1,925, 1,913, and 907 μM, respectively).2 It increases the wound closure rate in scratch-wounded HaCaT monolay...
T36691 Erythromycin 2'-Propionate

Others Others
Erythromycin 2'-propionate is a macrolide antibiotic and an esterified form of erythromycin .1It is active againstS. aureuswhen used at a concentration of 1 μg/ml. Erythromycin 2'-propionate (1 mM) inhibits protein synthesis in a cell-free assay. 1.Tardrew, P.L., Mao, J.C.H., and Kenney, D.Antibacterial activity of 2'-esters of erythromycinAppl. Microbiol.18(2)159-165(1969)
T36137 Biotin (S)-sulfoxide

Others Others
Biotin (S)-sulfoxide is an inactive metabolite of the coenzyme biotin .1,2It has also been found inE. coliand is reduced by the biotin sulfoxide reduction system as a source of biotin.3 1.Denkel, L.A., Rhen, M., and Bange, F.-C.Biotin sulfoxide reductase contributes to oxidative stress tolerance and virulence in Salmonella enterica serovar TyphimuriumMicrobiology (Reading)159(Pt 7)1447-1458(2013) 2.Carling, R.S., and Turner, C.Methods for assessment of biotin (Vitamin B7)Laboratory assessment of...
T38123 5(6)-Carboxy-2′,7′-dichlorofluorescein diacetate

5(6)-Carboxy-2’,7’-dichlorofluorescein diacetate is an oxidant-sensitive and cell-permeable fluorescent probe.1Base hydrolysis of the ester bonds by intracellular esterases releases the acetate groups and the resulting compound, 5(6)-carboxy-2’,7’,-dichlorofluorescein, is oxidized by reactive oxygen species (ROS) and nitric oxide (NO) and displays excitation/emission maxima of 504 and 530 nm, respectively, which can be quantified as a measure of oxidant production. 1.Hempel, S.L., Buettner, G.R....

化合物

IS-159
Cat.No: T27628
Synonym: IS 159,IS159
Target: Others
DJ-V-159
Cat.No: T5100
Synonym: DJ-V159
Target: GPR, Androgen Receptor
ETC-159
Cat.No: T4043
Synonym: ETC159,ETC-1922159,ETC 159
Target: Wnt/beta-catenin, Porcupine
U75302
Cat.No: T29034
Synonym: U 75302,U-75302
Target: Others
FMF-04-159-2
Cat.No: T11309
Synonym:
Target: CDK
Antibacterial agent 159
Cat.No: T79774
Synonym:
Target: Antibiotic
CV-159
Cat.No: T15021
Synonym:
Target: Others
Ovalbumin (154-159)
Cat.No: T80099
Synonym:
Target: Angiotensin-converting Enzyme (ACE)
AZ-PFKFB3-67 quarterhydrate
Cat.No: T62894
Synonym:
Target: Others
JWH-167
Cat.No: T32337
Synonym: JWH 167,JWH167
Target: Others
JH-XI-10-02
Cat.No: T13743
Synonym:
Target: EGFR, PROTACs
anti-TNBC agent-1
Cat.No: T39815
Synonym:
Target: Others
Salazinic Acid
Cat.No: T35671
Synonym:
Target: Others
Erythromycin 2'-Propionate
Cat.No: T36691
Synonym:
Target: Others
Biotin (S)-sulfoxide
Cat.No: T36137
Synonym:
Target: Others
5(6)-Carboxy-2′,7′-dichlorofluorescein diacetate
Cat.No: T38123
Synonym:
Target:
Cat. No. Product Name Species Expression System
TMPJ-00334 TGFBR2 Protein, Mouse, Recombinant (aa 24-159, hFc)

TGF-β receptor type II,Tgfbr2,TGF-β receptor type-2,TGF-β ty...

Mouse HEK293 Cells
TGFBR2 Protein, Mouse, Recombinant (aa 24-159, hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 55-65 KDa and the accession number is Q62312-2.

重组蛋白

TGFBR2 Protein, Mouse, Recombinant (aa 24-159, hFc)
Cat.No: TMPJ-00334
Species: Mouse
Expression System: HEK293 Cells
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