| Cat. No. | Product Name | Target | Signaling Pathways |
|---|---|---|---|
| T27628 |
IS-159
IS159,IS 159 |
||
| IS-159, a 5-HT1D agonist, is used potentially for the treatment of migraine. | |||
| T4043 |
ETC-159
ETC159,ETC-1922159,ETC 159 |
Wnt/beta-catenin; Porcupine | Cytoskeletal Signaling; Stem Cells |
| ETC159 是一种具有口服活性的，有效 PORCN 抑制剂。抑制β-catenin 报告基因活性的 IC50值为2.9 nM。 | |||
| T5100 |
DJ-V-159
DJ-V159 |
GPR; Androgen Receptor | Endocrinology/Hormones; GPCR/G Protein |
| DJ-V-159 是一种G 蛋白偶联受体家族C 组6 A 的激动剂。 | |||
| T15021 | CV-159 | Others | Others |
| CV-159 is a unique dihydropyridine Ca2+ antagonist with antiinflammatory activities. It has an anti-calmodulin (CaM) action. | |||
| T11309 | FMF-04-159-2 | CDK | Cell Cycle/Checkpoint |
| FMF-04-159-2 inhibits CDK14 and CDK2 with IC50s of 39.6 nM and 256 nM in NanoBRET assay, respectively. FMF-04-159-2 is a covalent CDK14 inhibitor. | |||
| T33455 |
MM 159
MM-159,MM159,Probimane |
||
| MM 159 (Probimane) is an anticancer agent that specifically targets cancer metastasis and is a cardioprotective agent for anthracyclines. MM 159 is active against a wider variety of tumors in vivo and in vitro, which in some cases may make it superior to | |||
| T29034 |
U75302
U 75302,U-75302 |
||
| U75302 is an antagonist of thymosin beta-4 (TB4) receptor with a Ki value of 159 nM on guinea pig lung membranes. | |||
| T32337 |
JWH-167
JWH167,JWH 167 |
||
| JWH 167, a synthetic cannabinoid (CB), has moderate affinities for central CB1 (Ki = 90 nM) and peripheral CB2 (Ki = 159 nM) receptors. Its physiological and toxicological properties have not been evaluated. This product is only applied for forensic and r | |||
| T62894 | AZ-PFKFB3-67 quarterhydrate | ||
| AZ-PFKFB3-67 quarterhydrate 是一种选择性的、高效的代谢激酶 PFKFB3 激酶抑制剂，作用于 PFKFB3 (IC50: 11 nM)、PFKFB2 (IC50: 159 nM) 和 PFKFB1 (IC50: 1130 nM)。 | |||
| T13743 | JH-XI-10-02 | EGFR | Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors |
| JH-XI-10-02 causes proteasomal degradation, does not affect CDK8 mRNA levels. JH-XI-10-02 shows no effect on CDK19. JH-XI-10-02 is a potent and selective degrader of CDK8, with an IC50 of 159 nM, based on PROTAC. | |||
| T39815 | Anti-TNBC agent-1 | ||
| anti-TNBC agent-1 is a highly effective compound specifically designed to target and combat triple-negative breast cancer (TNBC). It demonstrates remarkable potency against various breast cancer cell types, with IC50 values spanning from 0.20 μM to 0.27 μM. The mechanism of action of anti-TNBC agent-1 involves inducing apoptosis in SUM-159 cells through the mitochondria pathway, as well as causing G1 phase arrest in these cells. | |||
| T36675 | ERK Inhibitor | ||
| ERK inhibitor is a cell-permeable inhibitor that binds ERK2 near its docking domain (KD = 5 μM). This prevents its interaction with protein substrates without inhibiting catalytic activity. ERK inhibitor blocks ERK-specific phosphorylation of ribosomal S6 kinase-1 and ternary complex factor Elk-1 but does not affect ERK1/2 phosphorylation by MEK1/2. Presumably through its effects on ERK, ERK inhibitor completely prevents proliferation of HeLa cells (IC50 = 15-20 μM), A549 lung carcinoma cells (I... | |||
| T35671 | Salazinic Acid | ||
| Salazinic acid is a depsidone lichen metabolite that has been found in P. sulcata.1 It is active against B. cereus, B. subtilis, S. aureus, P. aeruginosa, S. typhimurium, C. albicans, and A. niger in vitro (MICs = 3.9-30.8 mM). Salazinic acid is cytotoxic to MM98, A431, and HaCaT cells in crystal violet (EC50s = 159, 2,870, and 48 μM, respectively) and neutral red uptake assays (EC50s = 1,925, 1,913, and 907 μM, respectively).2 It increases the wound closure rate in scratch-wounded HaCaT monolay... | |||
| T35954 | Allantoic acid | ||
| Allantoic acid is a degradative product of uric acid and associated with purine metabolism[1][2][3]. [1]. Taherkhani A, et, al. Metabolomic Analysis of Membranous Glomerulonephritis: Identification of a Diagnostic Panel and Pathogenic Pathways. Arch Med Res. 2019 May; 50(4):159-169. [2]. Okumura I, et, al. Stereospecificity of conversion of uric acid into allantoic acid by enzymes of Canadida utilis. J Biochem. 1976 May;79(5):1013-9. [3]. Cai HL, et, al. Therapeutic efficacy of atypical antipsyc... | |||
| T36691 | Erythromycin 2'-Propionate | ||
| Erythromycin 2'-propionate is a macrolide antibiotic and an esterified form of erythromycin .1It is active againstS. aureuswhen used at a concentration of 1 μg/ml. Erythromycin 2'-propionate (1 mM) inhibits protein synthesis in a cell-free assay. 1.Tardrew, P.L., Mao, J.C.H., and Kenney, D.Antibacterial activity of 2'-esters of erythromycinAppl. Microbiol.18(2)159-165(1969) | |||
| T36137 | Biotin (S)-sulfoxide | ||
| Biotin (S)-sulfoxide is an inactive metabolite of the coenzyme biotin .1,2It has also been found inE. coliand is reduced by the biotin sulfoxide reduction system as a source of biotin.3 1.Denkel, L.A., Rhen, M., and Bange, F.-C.Biotin sulfoxide reductase contributes to oxidative stress tolerance and virulence in Salmonella enterica serovar TyphimuriumMicrobiology (Reading)159(Pt 7)1447-1458(2013) 2.Carling, R.S., and Turner, C.Methods for assessment of biotin (Vitamin B7)Laboratory assessment of... | |||
| TMPY-00904 | Urokinase/uPA Protein, Human, Recombinant (His Tag), HPLC-verified | ||
| Plasminogen activator, urokinase, also known as PLAU and uPA, is a serine protease which converts plasminogen to plasmin, a broad-spectrum protease active on extracellular matrix (ECM) components. It is involved in complement activation, cell migration, wound healing, and generation of localized extracellular proteolysis during tissue remodelling, pro-hormone conversion, carcinogenesis and neoplasia. Like many components of the blood coagulation, fibrinolytic and complement cascades, uPA has a m... | |||
| TMPY-04504 | Urokinase/uPA Protein, Rat, Recombinant (His Tag) | ||
| Plasminogen activator, urokinase, also known as PLAU and uPA, is a serine protease which converts plasminogen to plasmin, a broad-spectrum protease active on extracellular matrix (ECM) components. It is involved in complement activation, cell migration, wound healing, and generation of localized extracellular proteolysis during tissue remodelling, pro-hormone conversion, carcinogenesis and neoplasia. Like many components of the blood coagulation, fibrinolytic and complement cascades, uPA has a m... | |||
| T38123 | 5(6)-Carboxy-2′,7′-dichlorofluorescein diacetate | ||
| 5(6)-Carboxy-2’,7’-dichlorofluorescein diacetate is an oxidant-sensitive and cell-permeable fluorescent probe.1Base hydrolysis of the ester bonds by intracellular esterases releases the acetate groups and the resulting compound, 5(6)-carboxy-2’,7’,-dichlorofluorescein, is oxidized by reactive oxygen species (ROS) and nitric oxide (NO) and displays excitation/emission maxima of 504 and 530 nm, respectively, which can be quantified as a measure of oxidant production. 1.Hempel, S.L., Buettner, G.R.... | |||
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