IS-159

IS-159, a 5-HT1D agonist, is used potentially for the treatment of migraine.

SR-3306 一种脑渗透性和选择性泛 JNK （JNK1 2 3） 抑制剂， IC50值分别为67 nM，283 nM，159 nM，并可减少食物摄入量和体重。

Biotin (S)-sulfoxide is an inactive metabolite of the coenzyme biotin .1,2It has also been found inE. coliand is reduced by the biotin sulfoxide reduction system as a source of biotin.3 1.Denkel, L.A., Rhen, M., and Bange, F.-C.Biotin sulfoxide reductase contributes to oxidative stress tolerance and virulence in Salmonella enterica serovar TyphimuriumMicrobiology (Reading)159(Pt 7)1447-1458(2013) 2.Carling, R.S., and Turner, C.Methods for assessment of biotin (Vitamin B7)Laboratory assessment of vitamin status193-217(2019) 3.del Campillo-Campbell, A., Dykhuizen, D., and Clearly, P.P.Enzymic reduction of d-biotin d-sulfoxide to d-biotinMethods Enzymol.62379-385(1979)

Dazopride is an antiemetic agent.

FMF-04-159-2是一种高效的共价型细胞周期蛋白依赖性激酶14（CDK14）抑制剂，对CDK14和CDK2的IC₅₀分别为39.6 nM和256 nM。FMF-04-159-2能够减少α-突触核蛋白（α-Syn）在神经元中的聚集并在帕金森病模型中发挥作用，也能够通过减弱Wnt β-catenin信号抑制三阴性乳腺癌（TNBC）的进展和转移。

JH-XI-10-02 causes proteasomal degradation, does not affect CDK8 mRNA levels. JH-XI-10-02 shows no effect on CDK19. JH-XI-10-02 is a potent and selective degrader of CDK8, with an IC50 of 159 nM, based on PROTAC.

CV-159 is a unique dihydropyridine Ca2+ antagonist with antiinflammatory activities. It has an anti-calmodulin (CaM) action.

SMD-3236是一种基于SMARCA配体和VHL-1配体设计的PRAOTAC降解剂，专门针对SMARCA2，展示了体内的长效抗肿瘤活性。SMARCA2是SMARCA4缺陷癌细胞中的合成致死靶点，SMD-3236对SMARCA2的降解选择性是SMARCA4的2000倍，DC50< 1 nM，Dmax>95%。SMD-3236可诱导肿瘤组织的SMARCA2缺失，同时保留SMARCA4蛋白，并在H838 smarca4缺陷人类癌症异种移植模型中抑制肿瘤生长。SMD-3236由靶蛋白配体(red part) SMI-1074、 PROTAC linker (black part) (trans-4-Ethynylcyclohexyl) methyl methanesulfonate 和E3连接酶配体(blue part)SMARCA2 ligand-14组成，其中E3连接酶配体和linker构成偶联物E3LigaseLigand-linker Conjugate 159。

E3 Ligase Ligand-linker Conjugate 159 是一种E3 连接酶配体-连接子偶联物 (E3 Ligase Ligand-linker conjugate)，可用于合成 SMD-3236，这是一种靶向降解 SMARCA2 的 PRAOTAC，在体内表现出长效抗肿瘤活性。

U75302 is an antagonist of thymosin beta-4 (TB4) receptor with a Ki value of 159 nM on guinea pig lung membranes.

JWH 167, a synthetic cannabinoid (CB), has moderate affinities for central CB1 (Ki = 90 nM) and peripheral CB2 (Ki = 159 nM) receptors. Its physiological and toxicological properties have not been evaluated. This product is only applied for forensic and r

Erythromycin 2'-propionate is a macrolide antibiotic and an esterified form of erythromycin .1It is active againstS. aureuswhen used at a concentration of 1 μg/ml. Erythromycin 2'-propionate (1 mM) inhibits protein synthesis in a cell-free assay. 1.Tardrew, P.L., Mao, J.C.H., and Kenney, D.Antibacterial activity of 2'-esters of erythromycinAppl. Microbiol.18(2)159-165(1969)

anti-TNBC agent-1 is a highly effective compound specifically designed to target and combat triple-negative breast cancer (TNBC). It demonstrates remarkable potency against various breast cancer cell types, with IC50 values spanning from 0.20 μM to 0.27 μM. The mechanism of action of anti-TNBC agent-1 involves inducing apoptosis in SUM-159 cells through the mitochondria pathway, as well as causing G1 phase arrest in these cells.

ETC-159 (ETC-1922159) 是一种具有口服活性的，有效 PORCN 抑制剂。抑制β-catenin 报告基因活性的 IC50值为2.9 nM。

DJ-V-159 (DJ-V159) 是一种G 蛋白偶联受体家族C 组6 A 的激动剂。

AZ-PFKFB3-67 quarterhydrate 是一种选择性的、高效的代谢激酶 PFKFB3 激酶抑制剂，作用于 PFKFB3 (IC50: 11 nM)、PFKFB2 (IC50: 159 nM) 和 PFKFB1 (IC50: 1130 nM)。

Antibacterialagent 159 (Compound 6d) 是一款高效抗菌化合物，具备针对脓疱疮和C. difficile感染（CDI）的抗菌活性。其使用过程中未发现C. difficile复发现象，并对益生肠道菌群仅有微弱影响。

Ovalbumin (154-159)为卵清蛋白片段，同时作为一种有效的血管紧张素转换酶 (ACE) 抑制剂，适用于高血压研究。

IL-17 modulator2 (compound 159) 为一种具有口服活性的IL-17调节剂，能够显著减少 IL-6、IFN-γ 及水肿的表现。该化合物主要应用于关节炎的研究领域。