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Targets Recommended: Apoptosis Kinesin

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Cat. No. Product Name Target Signaling Pathways
T9682 AZD-4877

AZD4877

Apoptosis; Kinesin Apoptosis; Cytoskeletal Signaling
AZD-4877 是一种高效的纺锤体驱动蛋白 (Eg5) 抑制剂,对其 IC50 值为 2 nM。 AZD-4877 是 Ispinesib 的另一种构型, 能够抑制细胞有丝分裂,诱导形成单极纺锤体表型,介导细胞凋亡(Apoptosis)。 AZD-4877 具有抗肿瘤活性,对循环外周血单核细胞 (PBMC)有抑制作用。
T68743 AZD4877 HCl

Others Others
AZD4877 is a synthetic kinesin spindle protein (KSP) inhibitor with potential antineoplastic activity. KSP inhibitor AZD4877 selectively inhibits microtubule motor protein KSP (also called kinesin-5 or Eg5), which may result in the inhibition of mitotic spindle assembly; activation of the spindle assembly checkpoint; induction of cell cycle arrest during the mitotic phase; and cell death in tumor cells that are actively dividing. Because KSP is not involved in postmitotic processes, such as neur...

化合物

AZD-4877
Cat.No: T9682
Synonym: AZD4877
Target: Apoptosis, Kinesin
AZD4877 HCl
Cat.No: T68743
Synonym:
Target: Others
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