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2742623-88-5

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  • 抑制剂&激动剂
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    TargetMol | Inhibitors_Agonists
  • Difelikefalin TFA
    T695302742623-88-5
    Difelikefalin TFA is a κ-opioid receptor (KOR) agonist. It activates KOR in HEK293 cells expressing the human receptor (EC50 = 0.16 nM in a transactivation assay) and inhibits forskolin-induced cAMP production in R1.G1 mouse thyoma cells (EC50 = 0.048 nM). Difelikefalin TFA is selective for KOR over the μ-opioid receptor (MOR; EC50 = >1 µM in a transactivation assay). It reduces acetic acid-induced writhing, as well as scratching behavior induced by the KOR antagonist GNTI, in mice (ED50s = 0.07 and 0.05 mg kg, respectively).
    • ¥ 13900
    8-10周
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  • TargetMol
    difelikefalin acetate(1024828-77-0 Free base)
    TP24852803411-76-7
    Difelikefalin acetate (CR 845 acetate) 是一种外周受限的 kappa 阿片受体激动剂。CR845 表现出低 P450 CYP 抑制和对大脑的低渗透性。
    • ¥ 990
    In stock
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    数量
  • TargetMol
    Difelikefalin (trifluoroacetate salt)
    T37483
    Difelikefalin is a κ-opioid receptor (KOR) agonist.1It activates KOR in HEK293 cells expressing the human receptor (EC50= 0.16 nM in a transactivation assay) and inhibits forskolin-induced cAMP production in R1.G1 mouse thyoma cells (EC50= 0.048 nM). Difelikefalin is selective for KOR over the μ-opioid receptor (MOR; EC50= >1 μM in a transactivation assay). It reduces acetic acid-induced writhing, as well as scratching behavior induced by the KOR antagonist GNTI, in mice (ED50s = 0.07 and 0.05 mg/kg, respectively). 1.Schteingart, C.D., Menzaghi, F., Jiang, G., et al.Synthetic peptide amides(2008)
    • ¥ 1178
    待询
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  • TargetMol
    Difelikefalin
    FE-202845, CR-845
    T384191024828-77-0
    Difelikefalin (CR-845; FE-202845) is a peripherally restricted, selective agonist of the kappa opioid receptor (KOR). It exhibits anti-inflammatory properties and holds promise for modulating pruritus in conditions associated with chronic kidney disease.
    • ¥ 1820
    5日内发货
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  • TargetMol
    Difelikefalin HCl
    T695372711717-77-8
    Difelikefalin HCl is a κ-opioid receptor (KOR) agonist. It activates KOR in HEK293 cells expressing the human receptor (EC50 = 0.16 nM in a transactivation assay) and inhibits forskolin-induced cAMP production in R1.G1 mouse thyoma cells (EC50 = 0.048 nM). Difelikefalin HCl is selective for KOR over the μ-opioid receptor (MOR; EC50 = >1 µM in a transactivation assay). It reduces acetic acid-induced writhing, as well as scratching behavior induced by the KOR antagonist GNTI, in mice (ED50s = 0.07 and 0.05 mg/kg, respectively).
    • ¥ 13900
    8-10周
    规格
    数量
  • TargetMol
    Difelikefalin acetate
    FE 202845 acetate, Difelikefalin醋酸盐, Difelikefalin acetate(1024828-77-0 free base), CR 845 acetate
    TP25012803411-76-7
    Difelikefalin acetate (CR 845 acetate) 是一种外周受限的 kappa 阿片受体激动剂。CR845 表现出低 P450 CYP 抑制和对大脑的低渗透性。
    • ¥ 990
    In stock
    规格
    数量