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YKL-40/CHI3L1 Protein, Human, Recombinant (His)

产品编号 TMPY-01304

别名: YKL-40, CGP-39, HC-gp39, GP39, DKFZp686N19119, HCGP-3P, GP-39, chitinase 3 like 1, FLJ38139, hCGP-39, YKL40, YYL-40, ASRT7

YKL-40/CHI3L1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 42 kDa and the accession number is A0A024R969.

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YKL-40/CHI3L1 Protein, Human, Recombinant (His)

规格	价格/CNY		货期	数量
100 μg	￥ 3,820		现货
200 μg	￥ 6,750		5日内发货
500 μg	￥ 14,280		5日内发货

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生物活性	Testing in progress
产品描述	YKL-40/CHI3L1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 42 kDa and the accession number is A0A024R969.

种属	Human
表达系统	HEK293 Cells
标签	C-His
蛋白编号	A0A024R969
别名	YKL-40, CGP-39, HC-gp39, GP39, DKFZp686N19119, HCGP-3P, GP-39, chitinase 3 like 1, FLJ38139, hCGP-39, YKL40, YYL-40, ASRT7
蛋白构建	The Human CHI3L1 (NP_001267.2) (Met 1-Thr 383) was fused with a polyhistidine tag at the C-terminus.
蛋白纯度	> 95 % as determined by SDS-PAGE
分子量	42 kDa (predicted)

内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, 10% Glycerol, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	Chitinase-3-like protein 1 (CHI3L1) is a secreted heparin-binding glycoprotein whose expression is associated with vascular smooth muscle cell migration. CHI3L1 is expressed at high levels in postconfluent nodular VSMC cultures and at low levels in subconfluent proliferating cultures. CHI3L1 is a tissue-restricted, chitin-binding lectin and member of glycosyl hydrolase family 18. In contrast to many other monocyto / macrophage markers, its expression is absent in monocytes and strong induced during late stages of human macrophage differentiation. Elevated levels of CHI3L1 are associated with disorders exhibiting increased connective tissue turnover, such as rheum atoid, arthritis, osteoarthritis, scleroderma, and cirrhosis of liver, but is produced in cartilage from old donors or patiens with osteoarthritis. CHI3L1 is abnormally expressed in the hippocampus of subjects with schizophrenia and may be involved in the cellular response to various environmental events that are reported to increase the risk of schizophrenia.

参考文献

1. Zhao XZH,et al.(2007) Functional Variants in the Promoter Region of Chitinase 3-Like 1 (CHI3L1) and Susceptibility to Schizophrenia.The American Journal of Human Genetics. 80 (1): 12-18. 2. Rehli M,et al.(2003) Transcriptional Regulation of CHI3L1, a Marker Gene for Late Stages of Macrophage Differentiation . The Journal of Biological Chemistry. 278: 44058-67. 3. Nishikawa KC,et al.(2003) gp38k (CHI3L1) is a novel adhesion and migration factor for vascular cells. Experimental Cell Research. 287 (1): 79-87

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Keywords

YKL-40/CHI3L1 Protein, Human, Recombinant (His) FLJ-38139 GP 39 YKL-40 CGP-39 HC-gp39 GP39 DKFZp686N19119 HCGP-3P CGP39 GP-39 chitinase 3 like 1 DKFZp686N-19119 ASRT 7 YYL40 FLJ38139 FLJ 38139 hCGP-39 DKFZp686N 19119 ASRT-7 YKL40 YYL-40 CGP 39 ASRT7 YYL 40 YKL 40 recombinant recombinant-proteins proteins protein

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