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IL-4 Protein, Human, Recombinant

IL-4 Protein, Human, Recombinant

产品编号 TMPY-01862
别名: Interleukin-4, IL-4, BCGF1, 白细胞介素, interleukin 4, BSF1, BSF-1, BCGF-1, 白介素

IL-4 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 15.1 kDa and the accession number is P05112-1.

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IL-4 Protein, Human, Recombinant
规格 价格/CNY 货期 数量
20 μg ¥ 1,750 现货
100 μg ¥ 4,430 5日内发货
200 μg ¥ 6,910 5日内发货
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产品目录号及名称: IL-4 Protein, Human, Recombinant (TMPY-01862)
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生物活性
技术参数
产品性质
参考文献
生物活性 Measured in a cell proliferation assay using TF-1 human erythroleukemic cells. The ED50 for this effect is 0.05-0.25 ng/mL.

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产品描述 IL-4 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 15.1 kDa and the accession number is P05112-1.
种属 Human
表达系统 E. coli
标签 Tag Free
蛋白编号 P05112-1
别名 Interleukin-4, IL-4, BCGF1, 白细胞介素, interleukin 4, BSF1, BSF-1, BCGF-1, 白介素
蛋白构建 The mature form of Human IL4 isoform 1 (P05112-1) (His 25-Ser 153) was expressed and purified with an initial Met.
蛋白纯度 ≥ 95 % as determined by SDS-PAGE. ≥ 95 % as determined by SEC-HPLC.

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分子量 15.1 kDa (predicted)
内毒素 < 5 EU/mg of the protein.
缓冲液 Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法 A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储

It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

运输方式

In general, Lyophilized powders are shipping with blue ice.

研究背景 Interleukin-4, also known as IL4, is a secreted protein that belongs to the IL-4 / IL-13 family. Interleukin-4 / IL4 has many biological roles, including the stimulation of activated B-cell and T-cell proliferation. It enhances both secretion and cell surface expression of IgE and IgG1. Interleukin-4 / IL4 also regulates the expression of the low-affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Interleukin-4 is essential for the switching of B cells to IgE antibody production and the maturation of T helper (Th) cells toward the Th2 phenotype. It participates in at least several B-cell activation processes as well as other cell types. However, studies show that double mutant (Q116D, Y119D) of the murine IL4 protein (QY), both glutamine 116 and tyrosine 119, which binds to the IL4 receptor alpha, completely inhibits in a dose-dependent manner the IL4-induced proliferation of lipopolysaccharide-stimulated murine splenic B-cells, of the murine T cell line CTLL-2, and the murine pre-B-cell line BA/F3. QY also inhibited the IL4-stimulated up-regulation of CD23 expression by lipopolysaccharide-stimulated murine splenic B-cells and abolished tyrosine phosphorylation of the transcription factor Stat6 and the tyrosine kinase Jak3 in IL4-stimulated BA/F3 cells.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy

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Keywords

IL-4 Protein, Human, Recombinant BSF 1 Interleukin-4 IL-4 BCGF 1 BCGF1 白细胞介素 interleukin 4 BSF1 IL4 IL 4 BSF-1 BCGF-1 白介素 recombinant recombinant-proteins proteins protein

 

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