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IL-18 Protein, Human, Recombinant (GST)

IL-18 Protein, Human, Recombinant (GST)

产品编号 TMPY-03381
别名: IL-18, IL-1g, 白介素, IGIF, 白细胞介素, IL1F4, interleukin 18

IL-18 Protein, Human, Recombinant (GST) is expressed in E. coli expression system with GST tag. The predicted molecular weight is 48.6 kDa and the accession number is Q14116.

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IL-18 Protein, Human, Recombinant (GST)
规格 价格/CNY 货期 数量
50 μg ¥ 2,940 5日内发货
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产品目录号及名称: IL-18 Protein, Human, Recombinant (GST) (TMPY-03381)
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生物活性 inactive
产品描述 IL-18 Protein, Human, Recombinant (GST) is expressed in E. coli expression system with GST tag. The predicted molecular weight is 48.6 kDa and the accession number is Q14116.
种属 Human
表达系统 E. coli
标签 N-GST
蛋白编号 Q14116
别名 IL-18, IL-1g, 白介素, IGIF, 白细胞介素, IL1F4, interleukin 18
蛋白构建 The pro form of Human IL18 (Q14116) (Met1-Asp193) was fused with the GST tag at the N-terminus.
蛋白纯度 > 85 % as determined by SDS-PAGE
分子量 48.6 kDa (predicted)
内毒素 Please contact us for more information.
缓冲液 Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.5. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法 A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储

It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

运输方式

In general, Lyophilized powders are shipping with blue ice.

研究背景 Interleukin-18 (IL-18, also known as interferon-gamma inducing factor) is a proinflammatory cytokine that belongs to the IL-1 superfamily and is produced by macrophages and other cells. This cytokine can induce the IFN-gamma production of T cells. The combination of IL-18 and IL12 has been shown to inhibit IL4 dependent IgE and IgG1 production, and enhance IgG2a production of B cells. IL-18 binding protein (IL18BP) can specifically interact with this cytokine, and thus negatively regulate its biological activity. IL-18 is an IL-1-like cytokine that requires cleavage with caspase-1 to become active, was found to increase IgE production in a CD4+ T cell -, IL-4- and STAT6-dependent fashion. IL-18 and T cell receptor-mediated stimulation could induce naive CD4+ T cells to develop into IL-4-producing cells in vitro. Thus, caspase-1 and IL-18 may be critical in the regulation of IgE production in vivo, providing a potential therapeutic target for allergic disorders. IL-18 production in primary synovial cultures and purified synovial fibroblasts was, in turn, upregulated by TNF-α and IL-1β, suggesting that monokine expression can feedback to promote Th1 cell development in the synovial membrane. Besides, synergistic combinations of IL-18, IL-12, and IL-15 may be of importance in sustaining both Th1 responses and monokine production in RA.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy

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Keywords

IL-18 Protein, Human, Recombinant (GST) IL-18 IL-1g 白介素 IL18 IL 18 IGIF 白细胞介素 IL1F4 interleukin 18 recombinant recombinant-proteins proteins protein

 

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