购物车

全部删除
您的购物车当前为空

IL-18 Protein, Mouse, Recombinant

一键复制产品信息

产品编号 TMPY-03273

IL-18 Protein, Mouse, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 18.2 kDa and the accession number is P70380-1.

IL-18 Protein, Mouse, Recombinant

一键复制产品信息

产品编号 TMPY-03273

IL-18 Protein, Mouse, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 18.2 kDa and the accession number is P70380-1.

规格	价格	库存
5 μg	¥ 687	6-8日内发货
10 μg	¥ 1,130	6-8日内发货
20 μg	¥ 1,890	In stock
50 μg	¥ 2,860	5日内发货
100 μg	¥ 3,930	5日内发货

大包装 & 定制

加入购物车

TargetMol 的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

选择批次

资源下载

COA 重组蛋白用户指南

产品信息

生物活性	Measured by its ability to induce IFN-γ secretion by KG-1 human myelomonocyte. The ED50 for this effect is typically 0.1-0.8 μg/mL.
产品描述	IL-18 Protein, Mouse, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 18.2 kDa and the accession number is P70380-1.
种属	Mouse
表达系统	E. coli
标签	Tag Free
蛋白编号	P70380-1
别名	白细胞介素,白介素,interleukin 18,Il-18,Igif
蛋白构建	A DNA sequence encoding the mouse IL18 (P70380-1) (Asn36-Ser192) was expressed and purified. Predicted N terminal: Met
蛋白纯度	> 90 % as determined by SDS-PAGE
分子量	18.2 kDa (predicted); 19 kDa (reducing conditions)
内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
蛋白性状	Lyophilized powder
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	Interleukin-18 (IL-18, also known as interferon-gamma inducing factor) is a proinflammatory cytokine that belongs to the IL-1 superfamily and is produced by macrophages and other cells. This cytokine can induce the IFN-gamma production of T cells. The combination of IL-18 and IL12 has been shown to inhibit IL4 dependent IgE and IgG1 production, and enhance IgG2a production of B cells. IL-18 binding protein (IL18BP) can specifically interact with this cytokine, and thus negatively regulate its biological activity. IL-18 is an IL-1-like cytokine that requires cleavage with caspase-1 to become active, was found to increase IgE production in a CD4+ T cell -, IL-4- and STAT6-dependent fashion. IL-18 and T cell receptor-mediated stimulation could induce naive CD4+ T cells to develop into IL-4-producing cells in vitro. Thus, caspase-1 and IL-18 may be critical in the regulation of IgE production in vivo, providing a potential therapeutic target for allergic disorders. IL-18 production in primary synovial cultures and purified synovial fibroblasts was, in turn, upregulated by TNF-α and IL-1β, suggesting that monokine expression can feedback to promote Th1 cell development in the synovial membrane. Besides, synergistic combinations of IL-18, IL-12, and IL-15 may be of importance in sustaining both Th1 responses and monokine production in RA.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy