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FGFR1 Protein, Human, Recombinant (His & GST)

产品编号 TMPY-04371

别名: HRTFDS, CEK, OGD, FLG, FLT2, FGFBR, bFGF-R-1, N-SAM, fibroblast growth factor receptor 1, HBGFR, HH2, KAL2, FLT-2, FGFR-1, CD331, BFGFR

FGFR1 Protein, Human, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 75 kDa and the accession number is H9FRD4.

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FGFR1 Protein, Human, Recombinant (His & GST)

规格	价格/CNY		货期	数量
50 μg	￥ 3,170		5日内发货

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生物活性	Kinase activity untested
产品描述	FGFR1 Protein, Human, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 75 kDa and the accession number is H9FRD4.

种属	Human
表达系统	Baculovirus Insect Cells
标签	His, GST
蛋白编号	H9FRD4
别名	HRTFDS, CEK, OGD, FLG, FLT2, FGFBR, bFGF-R-1, N-SAM, fibroblast growth factor receptor 1, HBGFR, HH2, KAL2, FLT-2, FGFR-1, CD331, BFGFR
蛋白构建	The Human FGFR1 isoform 4 (NP_075594.1) cytoplasmic domain (Gly 311-Arg 731) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
蛋白纯度	> 80 % as determined by SDS-PAGE
分子量	75 kDa (predicted)

内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液	Supplied as sterile 50 mM Tris, 100 mM NaCl, pH 8.0, 20% glycerol, 0.3 mM DTT.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store the product under sterile conditions at -20℃ to -80℃. Samples are stable for up to 12 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	Kinases are highly recommended to be shipped at frozen temperature with blue ice or dry ice.
研究背景	FGFR1, also known as CD331, belongs to the fibroblast growth factor receptor subfamily where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. Fibroblast growth factors (FGFs) (FGF1 - 10 and 16 - 23) are mitogenic signaling molecules that have roles in angiogenesis, wound healing, cell migration, neural outgrowth and embryonic development. FGFs bind heparan sulfate glycosaminoglycans, which facilitates dimerization (activation) of FGF receptors. FGFR1 is a full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of FGFR1 interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. CD331 can be detected in astrocytoma, neuroblastoma and adrenal cortex cell lines. Some isoforms are detected in foreskin fibroblast cell lines, however isoform 17, isoform 18 and isoform 19 are not detected in these cells. Defects in FGFR1 are a cause of Pfeiffer syndrome ，idiopathic hypogonadotropic hypogonadism， Kallmann syndrome type 2, osteoglophonic dysplasia and trigonocephaly non-syndromic.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy

参考文献

1. Schlessinger J,et al.(2000) Crystal structure of a ternary FGF-FGFR-heparin complex reveals a dual role for heparin in FGFR binding and dimerization. Mol Cell. 6(3):743-50. 2. Dodé C,et al.(2007) Novel FGFR1 sequence variants in Kallmann syndrome, and genetic evidence that the FGFR1c isoform is required in olfactory bulb and palate morphogenesis. Hum Mutat. 28(1): 97-8. 3. Kim HG,et al.(2005) Hypogonadotropic hypogonadism and cleft lip and palate caused by a balanced translocation producing haploinsufficiency for FGFR1. J Med Genet. 42(8):666-72.

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Keywords

FGFR1 Protein, Human, Recombinant (His & GST) FLT 2 HRTFDS HH 2 CEK KAL 2 FGFR1 FGFR 1 OGD FLG FLT2 FGFBR CD-331 bFGF-R-1 N-SAM CD 331 fibroblast growth factor receptor 1 HBGFR KAL-2 HH2 KAL2 FLT-2 FGFR-1 CD331 BFGFR HH-2 recombinant recombinant-proteins proteins protein

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