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ACVR2B Protein, Mouse, Recombinant (His & hFc)

产品编号 TMPY-01022

别名: ActRIIB, activin A receptor, type IIB, 4930516B21Rik

ACVR2B Protein, Mouse, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 41 kDa and the accession number is P27040-1.

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ACVR2B Protein, Mouse, Recombinant (His & hFc)

规格	价格/CNY		货期	数量
100 μg	￥ 3,820		5日内发货

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参考文献

生物活性	1. Measured by its ability to bind biotinylated Human INHBA-his in functional ELISA. 2. Measured by its ability to bind biotinylated mouse INHBA-his in functional ELISA. 3. Measured by its ability to neutralize Activin-mediated inhibition on MPC11 cell proliferation. The ED50 for this effect is typically 10-50 ng/mL in the presence of 10 ng/mL recombinant Activin A.
产品描述	ACVR2B Protein, Mouse, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 41 kDa and the accession number is P27040-1.

种属	Mouse
表达系统	HEK293 Cells
标签	His, hFc
蛋白编号	P27040-1
别名	ActRIIB, activin A receptor, type IIB, 4930516B21Rik
蛋白构建	The extracellular domain (Met 1-Thr 134) of Mouse ACVR2B (NP_031423.1) precursor was fused with the Fc region of Human IgG1 at the C-terminus.
蛋白纯度	> 97 % as determined by SDS-PAGE
分子量	41 kDa (predicted)

内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	ACVR2A and ACVR2B are two activin type II receptors. ACVR2B is integral to the activin and myostatin signaling pathway. Ligands such as activin and myostatin bind to ACVR2A and ACVR2B. Myostatin, a negative regulator of skeletal muscle growth, is regarded as a potential therapeutic target and binds to ACVR2B effectively, and to a lesser extent, to ACVR2A. The structure of human ACVR2B kinase domain in complex with adenine establishes the conserved bilobal architecture consistent with all other catalytic kinase domains. Haplotype structure at the ACVR2B and follistatin loci may contribute to interindividual variation in skeletal muscle mass and strength. Defects in ACVR2B are a cause of left-right axis malformations.

参考文献

1. Kosaki R,et al.(1999) Left-right axis malformations associated with mutations in ACVR2B, the gene for human activin receptor type IIB. Am J Med Genet. 82(1):70-6. 2. Dupont S,et al.(2001) No evidence for linkage or for diabetes-associated mutations in the activin type 2B receptor gene (ACVR2B) in French patients with mature-onset diabetes of the young or type 2 diabetes. Diabetes 50(5):1219-21. 3. Albertson RC,et al.(2005) Zebrafish acvr2a and acvr2b exhibit distinct roles in craniofacial development. Developmental dynamics 233(4): 1405-18. 4. Walsh S,et al.(2007) Activin-type II receptor B (ACVR2B) and follistatin haplotype associations with muscle mass and strength in humans. J Appl Physiol. 102(6):2142-8.

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Keywords

ACVR2B Protein, Mouse, Recombinant (His & hFc) ActRIIB activin A receptor, type IIB 4930516B21Rik recombinant recombinant-proteins proteins protein

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