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Anti-TGM2 Antibody (9Q248)
还可以产品编号 TMAH-01166
别名 transglutaminase 2, TGC, TG2, HEL-S-45, G-α-h, GNAH, G-ALPHA-h
Anti-TGM2 Antibody (9Q248) 是一种 Mouse 抗体，靶向 TGM2。Anti-TGM2 Antibody (9Q248) 可用于 ELISA, WB, IHC。
Anti-TGM2 Antibody (9Q248)
Anti-TGM2 Antibody (9Q248)
还可以产品编号 TMAH-01166 别名 transglutaminase 2, TGC, TG2, HEL-S-45, G-α-h, GNAH, G-ALPHA-h
Anti-TGM2 Antibody (9Q248) 是一种 Mouse 抗体，靶向 TGM2。Anti-TGM2 Antibody (9Q248) 可用于 ELISA, WB, IHC。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μg | ¥ 1,310 | 5日内发货 | |
| 100 μg | ¥ 2,185 | 5日内发货 |
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产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-TGM2 Antibody (9Q248) is a Mouse antibody targeting TGM2. Anti-TGM2 Antibody (9Q248) can be used in ELISA, WB, IHC. |
| 别名 | transglutaminase 2, TGC, TG2, HEL-S-45, G-α-h, GNAH, G-ALPHA-h |
| Ig Type | IgG |
| 克隆号 | 9Q248 |
| 交叉反应 | Human |
| 验证活性 | 1. Immunohistochemical of paraffin-embedded Human placenta tissue using TMAH-01166 at dilution of 1:200. 2. Immunohistochemical of paraffin-embedded Human Breast tissue using TMAH-01166 at dilution of 1:200. 3. Western Blot -All lanes: Mouse anti-TGM2 Monoclonal antibody at 1μg/ml -Lane 1 : A549 whole cell lysate -Secondary Goat polyclonal to Mouse IgG at 1/5000 dilution -Predicted band size :77kd -Observed band size :77,62,39KD -Additional bands at :30kd |
| 应用 | ELISA, WB, IHC |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 亚细胞定位 | Cytoplasm, cytosol. Nucleus. Chromosome. Secreted, extracellular space, extracellular matrix. Cell membrane. Mitochondrion.; [Isoform 2]: Cytoplasm, perinuclear region. |
| 构建方式 | Hybridoma Monoclonal Antibody |
| 纯化方式 | Protein G purified |
| 性状 | Liquid |
| 缓冲液 | Preservative: 0.03% Proclin 300. Constituents: 50% Glycerol, 0.01M PBS, PH 7.4. |
| 纯度 | >95% |
| 研究背景 | Calcium-dependent acyltransferase that catalyzes the formation of covalent bonds between peptide-bound glutamine and various primary amines, such as gamma-amino group of peptide-bound lysine, or mono- and polyamines, thereby producing cross-linked or aminated proteins, respectively. Involved in many biological processes, such as bone development, angiogenesis, wound healing, cellular differentiation, chromatin modification and apoptosis. Acts as a protein-glutamine gamma-glutamyltransferase by mediating the cross-linking of proteins, such as ACO2, HSPB6, FN1, HMGB1, RAP1GDS1, SLC25A4/ANT1, SPP1 and WDR54. Under physiological conditions, the protein cross-linking activity is inhibited by GTP; inhibition is relieved by Ca(2+) in response to various stresses. When secreted, catalyzes cross-linking of proteins of the extracellular matrix, such as FN1 and SPP1 resulting in the formation of scaffolds. Plays a key role during apoptosis, both by (1) promoting the cross-linking of cytoskeletal proteins resulting in condensation of the cytoplasm, and by (2) mediating cross-linking proteins of the extracellular matrix, resulting in the irreversible formation of scaffolds that stabilize the integrity of the dying cells before their clearance by phagocytosis, thereby preventing the leakage of harmful intracellular components. In addition to protein cross-linking, can use different monoamine substrates to catalyze a vast array of protein post-translational modifications: mediates aminylation of serotonin, dopamine, noradrenaline or histamine into glutamine residues of target proteins to generate protein serotonylation, dopaminylation, noradrenalinylation or histaminylation, respectively. Mediates protein serotonylation of small GTPases during activation and aggregation of platelets, leading to constitutive activation of these GTPases. Plays a key role in chromatin organization by mediating serotonylation and dopaminylation of histone H3. Catalyzes serotonylation of 'Gln-5' of histone H3 (H3Q5ser) during serotonergic neuron differentiation, thereby facilitating transcription. Acts as a mediator of neurotransmission-independent role of nuclear dopamine in ventral tegmental area (VTA) neurons: catalyzes dopaminylation of 'Gln-5' of histone H3 (H3Q5dop), thereby regulating relapse-related transcriptional plasticity in the reward system. Regulates vein remodeling by mediating serotonylation and subsequent inactivation of ATP2A2/SERCA2. Also acts as a protein deamidase by mediating the side chain deamidation of specific glutamine residues of proteins to glutamate. Catalyzes specific deamidation of protein gliadin, a component of wheat gluten in the diet. May also act as an isopeptidase cleaving the previously formed cross-links. Also able to participate in signaling pathways independently of its acyltransferase activity: acts as a signal transducer in alpha-1 adrenergic receptor-mediated stimulation of phospholipase C-delta (PLCD) activity and is required for coupling alpha-1 adrenergic agonists to the stimulation of phosphoinositide lipid metabolism. Has cytotoxic activity: is able to induce apoptosis independently of its acyltransferase activity. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Protein: Human Protein-glutamine gamma-glutamyltransferase 2(TGM2) |
| 抗原种属 | Human |
| 基因ID | 7052 |
| Uniprot ID | |
| 研究领域 | Cell Biology |
存储&运输
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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