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顶部生物活性储存和溶解信息计算器

Anti-Phospho-EIF2AK2 (Thr446) Polyclonal Antibody 2

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Anti-Phospho-EIF2AK2 (Thr446) Polyclonal Antibody 2
产品编号 TMAC-03356
别名 p68 kinase, EIF2AK2 (p-Thr446), EIF2AK2 (p-T446), EIF2AK2 (pT446), EIF2AK2 (phospho-Thr446), eIF2A protein kinase2

Anti-Phospho-EIF2AK2 (Thr446) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-EIF2AK2 (Thr446)。Anti-Phospho-EIF2AK2 (Thr446) Polyclonal Antibody 可用于 WB,IP,IF,IHC。

Anti-Phospho-EIF2AK2 (Thr446) Polyclonal Antibody 2

Anti-Phospho-EIF2AK2 (Thr446) Polyclonal Antibody 2

Rating icon 还可以
Anti-Phospho-EIF2AK2 (Thr446) Polyclonal Antibody 2
产品编号 TMAC-03356 别名 p68 kinase, EIF2AK2 (p-Thr446), EIF2AK2 (p-T446), EIF2AK2 (pT446), EIF2AK2 (phospho-Thr446), eIF2A protein kinase2

Anti-Phospho-EIF2AK2 (Thr446) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-EIF2AK2 (Thr446)。Anti-Phospho-EIF2AK2 (Thr446) Polyclonal Antibody 可用于 WB,IP,IF,IHC。

规格价格库存数量
50 μL
¥ 1,480
5日内发货
100 μL
¥ 2,490
5日内发货
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产品介绍

生物活性
产品描述
Anti-Phospho-EIF2AK2 (Thr446) Polyclonal Antibody is a Rabbit antibody targeting Phospho-EIF2AK2 (Thr446). Anti-Phospho-EIF2AK2 (Thr446) Polyclonal Antibody can be used in WB,IP,IF,IHC.
别名p68 kinase, EIF2AK2 (p-Thr446), EIF2AK2 (p-T446), EIF2AK2 (pT446), EIF2AK2 (phospho-Thr446), eIF2A protein kinase2
交叉反应
Human,Mouse,Rat
验证活性
1. Western blot analysis of phosphorylated PKR expression in K-562 (A) and starved K-562 (B) whole cell lysates.
2. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human colon carcinoma tissue showing cytoplasmic staining.
应用
WB
IP
IF
IHC
推荐剂量
WB: 1:100-1000; IHC: 1:50-500; IP: 1-2 μg per 100-500 μg of total protein(1 ml of cell lysate)
抗体种类
Polyclonal
宿主来源Rabbit
构建方式Polyclonal Antibody
纯化方式Immunogen affinity purified
性状Liquid
缓冲液1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
研究背景An interferon-inducible, RNA-dependent protein serine/threonine kinase, PKR has various designations. Mouse PKR is known as DAI, dsJ, PI kinase, p65, p67 or TIK, whereas human PKR is known as p68 or p69. PKR phosphorylates its substrate, a subunit of protein synthesis initiation factor eIF-2 on Ser 51 to inhibit translation. PKR contains two dsRNA binding motifs required for its activation by dsRNA. Three kinds of regulation of PKR enzymatic activity occur, and these include transcriptional regulation in response to interferon, an autoregulatory mechanism controlling PKR expression at the level of translation, and posttranslational regulation by RNA mediated autophosphorylation. Human PKR contains at least 15 autophosphorylation sites, but only Thr-446 and Thr-451 in the activation loop are critical for its kinase activity. Thr-446 is the in vivo autophosphorylation site of PKR. Mutation of threonine to alanine at position 446 substantially reduces PKR function, and mutant kinase containing Ala-451 is completely inactive.
偶联与修饰
偶联
Unconjugated
其他可选修饰符
Phospho
抗原信息
免疫原
Amino acid sequence containing phosphorylated Thr 446 of PKR of human origin
抗原种属
human
Uniprot ID
P19525
化学信息
分子量Theoretical: 68 kDa.
存储&运输
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

计算器

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关键词

Tyrosine-protein kinase EIF2AK2Protein kinase RNA-activated (PKRProtein kinase R)PRKRPKRPhospho-EIF2AK2 (T446)p-EIF2AK2 (Thr446)pEIF2AK2 (Thr446)p-EIF2AK2 (T446)pEIF2AK2 (T446)P1/eIF-2A protein kinaseInterferon-inducible RNA-dependent protein kinaseInterferon-induced, double-stranded RNA-activated protein kinaseEukaryotic translation initiation factor 2-α kinase 2 (eIF-2A protein kinase 2)Eukaryotic translation initiation factor 2-alpha kinase 2 (eIF-2A protein kinase 2)Eukaryotic translation initiation factor 2-a kinase 2 (eIF-2A protein kinase 2)EIF2AK2 (pThr446)EIF2AK2 (phospho-T446)EIF2AK2EIF2AK 2eIF-2A protein kinase 2double-stranded RNA-activated protein kinase

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