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Anti-p53 Antibody (7A906)
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产品编号 TMAC-02989
别名 Tumor suppressor p53, Tp53, P53, Cellular tumor antigen p53
Anti-p53 Antibody (7A906) 是一种 Rabbit 抗体，靶向 p53。Anti-p53 Antibody (7A906) 可用于 WB,ICC,IF,IHC。
Anti-p53 Antibody (7A906)
Anti-p53 Antibody (7A906)
还可以产品编号 TMAC-02989 别名 Tumor suppressor p53, Tp53, P53, Cellular tumor antigen p53
Anti-p53 Antibody (7A906) 是一种 Rabbit 抗体，靶向 p53。Anti-p53 Antibody (7A906) 可用于 WB,ICC,IF,IHC。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,490 | 5日内发货 | |
| 100 μL | ¥ 2,480 | 5日内发货 |
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产品介绍
生物活性
偶联与修饰
抗原信息
化学信息
| 产品描述 | Anti-p53 Antibody (7A906) is a Rabbit antibody targeting p53. Anti-p53 Antibody (7A906) can be used in WB,ICC,IF,IHC. |
| 别名 | Tumor suppressor p53, Tp53, P53, Cellular tumor antigen p53 |
| Ig Type | IgG |
| 交叉反应 | Human,Mouse,Rat |
| 验证活性 | 1. Western blot analysis of p53DINP1 on different cell lysates using anti-p53DINP1 at 1/500 dilution. Positive control: Line 1: SH-SY-5Y, Line 2: HepG2, Line 3: Mouse stomach, Line 3: Human stomach. 2. Immunohistochemical analysis of paraffin-embedded huamn liver cancer tissue using anti-p53DINP1 antibody. Counter stained with hematoxylin. 3. Immunohistochemical analysis of paraffin-embedded human kidney tissue using anti-p53DINP1 antibody. Counter stained with hematoxylin. 4. Immunohistochemical analysis of paraffin-embedded human pancreas tissue using anti-p53DINP1 antibody. Counter stained with hematoxylin. 5. ICC staining p53DINP1 in HepG2 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. 6. ICC staining p53DINP1 in HUVEC cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. |
| 应用 | |
| 推荐剂量 | WB: 1:500-1000; IHC: 1:50-200; ICC: 1:50-200 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 构建方式 | Recombinant Antibody |
| 纯化方式 | ProA affinity purified |
| 性状 | Liquid |
| 缓冲液 | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| 研究背景 | Antiproliferative and proapoptotic protein involved in cell stress response which acts as a dual regulator of transcription and autophagy. Acts as a positive regulator of autophagy. In response to cellular stress or activation of autophagy, relocates to autophagosomes where it interacts with autophagosome-associated proteins GABARAP, GABARAPL1/L2, MAP1LC3A/B/C and regulates autophagy. Acts as an antioxidant and plays a major role in p53/TP53-driven oxidative stress response. Possesses both a p53/TP53-independent intracellular reactive oxygen species (ROS) regulatory function and a p53/TP53-dependent transcription regulatory function. Positively regulates p53/TP53 and p73/TP73 and stimulates their capacity to induce apoptosis and regulate cell cycle. In response to double-strand DNA breaks, promotes p53/TP53 phosphorylation on 'Ser-46' and subsequent apoptosis. Acts as a tumor suppressor by inducing cell death by an autophagy and caspase-dependent mechanism. Can reduce cell migration by regulating the expression of SPARC. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Protein: Full length of human p53DINP1 |
| 抗原种属 | human |
| Uniprot ID |
| 分子量 | Theoretical: 27 kDa. |
存储&运输
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
计算器
比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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