Anti-FGFR3 Antibody (9A8)

Name: Anti-FGFR3 Antibody (9A8)
Brand: TargetMol
SKU: TMAH-00433
Rating: 4.5 (1 reviews)

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产品编号 TMAH-00433

别名 JTK4, HSFGFR3EX, FGFR3, FGFR2 α(IIIb), FGF R3, EC 2.7.10, CEK2, CEK, CD333, ACH

Anti-FGFR3 Antibody (9A8) 是一种抗体，靶向 FGFR3。Anti-FGFR3 Antibody (9A8) 可用于 ELISA, IF。

Anti-FGFR3 Antibody (9A8)

还可以

产品编号 TMAH-00433 别名 JTK4, HSFGFR3EX, FGFR3, FGFR2 α(IIIb), FGF R3, EC 2.7.10, CEK2, CEK, CD333, ACH

Anti-FGFR3 Antibody (9A8) 是一种抗体，靶向 FGFR3。Anti-FGFR3 Antibody (9A8) 可用于 ELISA, IF。

规格	价格	库存	数量
50 μL	¥ 1,300	5日内发货
100 μL	¥ 2,185	5日内发货

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生物活性

产品描述	Anti-FGFR3 Antibody (9A8) is an antibody targeting FGFR3. Anti-FGFR3 Antibody (9A8) can be used in ELISA, IF.
别名	JTK4, HSFGFR3EX, FGFR3, FGFR2 α(IIIb), FGF R3, EC 2.7.10, CEK2, CEK, CD333, ACH
Ig Type	Rabbit IgG
克隆号	9A8
交叉反应	Human
验证活性	Immunofluorescence staining of HepG2 Cells with TMAH-00433 at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeated by 0.2% TritonX-100, and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. Nuclear DNA was labeled in blue with DAPI. The secondary antibody was FITC-conjugated AffiniPure Goat Anti-Rabbit IgG (H+L).
应用	ELISA, IF
推荐剂量	IF:1:20-1:200.
抗体种类	Monoclonal
亚细胞定位	[Isoform 1]: Cell membrane; Single-pass type I membrane protein. Cytoplasmic vesicle. Endoplasmic reticulum. Note=The activated receptor is rapidly internalized and degraded. Detected in intracellular vesicles after internalization of the autophosphorylated receptor.; [Isoform 2]: Cell membrane; Single-pass type I membrane protein.; [Isoform 3]: Secreted.; [Isoform 4]: Cell membrane; Single-pass type I membrane protein.
构建方式	Recombinant Antibody
纯化方式	Affinity-chromatography
性状	Liquid
缓冲液	Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
研究背景	Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis. Plays an essential role in the regulation of chondrocyte differentiation, proliferation and apoptosis, and is required for normal skeleton development. Regulates both osteogenesis and postnatal bone mineralization by osteoblasts. Promotes apoptosis in chondrocytes, but can also promote cancer cell proliferation. Required for normal development of the inner ear. Phosphorylates PLCG1, CBL and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Plays a role in the regulation of vitamin D metabolism. Mutations that lead to constitutive kinase activation or impair normal FGFR3 maturation, internalization and degradation lead to aberrant signaling. Over-expressed or constitutively activated FGFR3 promotes activation of PTPN11/SHP2, STAT1, STAT5A and STAT5B. Secreted isoform 3 retains its capacity to bind FGF1 and FGF2 and hence may interfere with FGF signaling.

偶联与修饰

偶联	Unconjugated

抗原信息

免疫原	A synthetic peptide: Human FGFR3
抗原种属	Human
基因ID	2261
Uniprot ID	P22607
研究领域	Cancer, Cardiovascular, Signal transduction, Stem cells