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Anti-Cadherin 17/CDH17 Antibody (9M822)
还可以产品编号 TMAY-01848
Anti-Cadherin 17/CDH17 Antibody (9M822) 是一种 Mouse 抗体，靶向 Cadherin 17/CDH17。Anti-Cadherin 17/CDH17 Antibody (9M822) 可用于 IHC-P。
Anti-Cadherin 17/CDH17 Antibody (9M822)
Anti-Cadherin 17/CDH17 Antibody (9M822)
还可以产品编号 TMAY-01848
Anti-Cadherin 17/CDH17 Antibody (9M822) 是一种 Mouse 抗体，靶向 Cadherin 17/CDH17。Anti-Cadherin 17/CDH17 Antibody (9M822) 可用于 IHC-P。
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| 产品描述 | Anti-Cadherin 17/CDH17 Antibody (9M822) is a Mouse antibody targeting Cadherin 17/CDH17. Anti-Cadherin 17/CDH17 Antibody (9M822) can be used in IHC-P. |
| Ig Type | Monoclonal Mouse IgG2b |
| 克隆号 | 9M822 |
| 交叉反应 | Human |
| 验证活性 | 1. Immunochemical staining of human CDH17 in human rectal carcinoma (from 2 donors) with mouse monoclonal antibody (1:60, formalin-fixed paraffin embedded sections). The image showing membrane staining of intestinal gland. 2. Immunochemical staining of human CDH17 in human appendix with mouse monoclonal antibody (1:60, formalin-fixed paraffin embedded sections). The image showing membrane staining of intestinal gland. |
| 应用 | IHC-P |
| 推荐剂量 | IHC-P: 1:50-1:200 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human Cadherin-17 / LI-cadherin / CDH17 (rh Cadherin-17 / LI-cadherin / CDH17; TMPY-01912; Q12864-1; Met1-Met787). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | Cadherin-17 or LI-cadherin is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. Cadherin-17/LI-cadherin is a cadherin-like protein consisting of an extracellular region, 7 cadherin domains, and a transmembrane region but lacking the conserved cytoplasmic domain. The protein is a component of the gastrointestinal tract and pancreatic ducts, acting as an intestinal proton-dependent peptide transporter in the first step in oral absorption of many medically important peptide-based drugs. The protein may also play a role in the morphological organization of liver and intestine. Alternative splicing of the encoding gene results in multiple transcript variants. Cadherin-17/LI-cadherin preferentially interact with themselves in a homophilic manner in connecting cells. Cadherin-17 may thus contribute to the sorting of heterogeneous cell types and have a role in the morphological organization of liver and intestine. It's also involved in intestinal peptide transport. Experiments have reported the association between Cadherin-17/LI-cadherin and gastric cancer. Cadherin-17/LI-cadherin expression was detected in 63/94 of gastric adenocarcinomas in addition to intestinal metaplasia. The expression of Cadherin-17 tended to be associated with intestinal type carcinoma, and carcinomas with Cadherin-17 expression was significantly more frequent in advanced stage cases than in early stage. Cadherin-17 is also a useful immunohistochemical marker for diagnosis of adenocarcinomas of the digestive system. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Human Cadherin-17 / LI-cadherin / CDH17 protein (TMPY-01912) |
| 抗原种属 | Human |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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