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Anti-Annexin V/ANXA5 Antibody (4X413)
还可以产品编号 TMAY-00843
Anti-Annexin V/ANXA5 Antibody (4X413) 是一种 Mouse 抗体，靶向 Annexin V/ANXA5。Anti-Annexin V/ANXA5 Antibody (4X413) 可用于 ELISA。
Anti-Annexin V/ANXA5 Antibody (4X413)
Anti-Annexin V/ANXA5 Antibody (4X413)
还可以产品编号 TMAY-00843
Anti-Annexin V/ANXA5 Antibody (4X413) 是一种 Mouse 抗体，靶向 Annexin V/ANXA5。Anti-Annexin V/ANXA5 Antibody (4X413) 可用于 ELISA。
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抗原信息
| 产品描述 | Anti-Annexin V/ANXA5 Antibody (4X413) is a Mouse antibody targeting Annexin V/ANXA5. Anti-Annexin V/ANXA5 Antibody (4X413) can be used in ELISA. |
| Ig Type | Monoclonal Mouse IgG2b |
| 克隆号 | 4X413 |
| 交叉反应 | Human |
| 应用 | ELISA |
| 推荐剂量 | ELISA: 1:1000-1:2000 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human ANXA5 (rh ANXA5; TMPY-02540; P08758; Met1-Asp320). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | The placental anticoagulant protein Annexin A5 (ANXA5) is a multifunctional protein that is highly expressed on the apical surfaces of syncytiotrophoblasts, and plays an important role in haemostatic regulations, maintaining blood fluidity of the placenta. Annexin A5 (ANXA5) is a protein abundantly expressed in normal placenta where it contributes to the healthy outcome of a pregnancy. Lower ANXA5 levels have been observed in M2/ANXA5 haplotype carrying chorion. The association found between the maternal carriage of the M2/ANXA5 haplotype and an elevated risk of IUGR and/or PE supports the hypothesis that carrier status of this haplotype and the consequently reduced placental ANXA5 expression might be responsible, at least partially, for the onset of these gestational vascular complications. ANXA5 could be used as a biomarker for the early detection of PE and for the prediction of its severity. ANXA5 as an embryonic anticoagulant that appears deficient in contiguous specter of thrombophilia-related pregnancy complications culminating more frequently in miscarriage in a maternal M2 carrier background. As a potential indicator for malignancy and lymphatic metastasis, ANXA5 overexpression increases in vitro migration and invasion of Hca-P cell, promotes in vivo malignancy, LNM rate and level of Hca-P-transplanted mice. Hereditary thrombophilias can impair vascular placental functions and predispose to the birth of small-for-gestational age (SGA) babies. The placental anticoagulant protein annexin A5 (ANXA5) may contribute to this process. A functional haplotype (M2) within the ANXA5 gene is associated with fetal loss and venous thrombosis. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Human ANXA5 Protein (TMPY-02540) |
| 抗原种属 | Human |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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计算器
比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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