Powder: -20°C for 3 years | In solvent: -80°C for 1 year
S516 is an active CKD-516 metabolite and is a potent inhibitor of tubulin polymerization(IC50 of 4.29 μM), has marked antitumor activity.
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
2 mg | ¥ 1,710 | 5日内发货 | ||
5 mg | ¥ 2,890 | 5日内发货 | ||
25 mg | ¥ 10,500 | 6-8周 | ||
50 mg | ¥ 13,700 | 6-8周 | ||
100 mg | ¥ 17,500 | 6-8周 | ||
1 mL * 10 mM (in DMSO) | ¥ 2,780 | 5日内发货 |
产品描述 | S516 is an active CKD-516 metabolite and is a potent inhibitor of tubulin polymerization(IC50 of 4.29 μM), has marked antitumor activity. |
靶点活性 | Tubulin polymerization:4.29 μM |
体外活性 | S516 has potent cytotoxicity(HL-60, HCT116 and HCT15 cells with IC50s of 4.8 nM, 42.8 nM and 24.9 nM, respectively). S516 (30 nM; 16 hours; HL60 cells) treatmemt causes significant arrest of cells at the G2/M phase, resulting in apoptosis with concomitant loss of G0/G1 phase. |
体内活性 | In human LX-1 lung cancer and CX-1 colon cancer mouse xenografts,S516 (5-10 mg/kg; intraperitoneal injection; mice) treatment has promising antitumor activity (inhibition ratio (IR)> 63%) . |
分子量 | 437.47 |
分子式 | C21H19N5O4S |
CAS No. | 1016543-77-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 12.5 mg/mL (28.57 mM), Sonication is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.2859 mL | 11.4294 mL | 22.8587 mL | 57.1468 mL |
5 mM | 0.4572 mL | 2.2859 mL | 4.5717 mL | 11.4294 mL | |
10 mM | 0.2286 mL | 1.1429 mL | 2.2859 mL | 5.7147 mL | |
20 mM | 0.1143 mL | 0.5715 mL | 1.1429 mL | 2.8573 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
S516 1016543-77-3 Cytoskeletal Signaling Microtubule Associated S-516 S 516 Inhibitor inhibitor inhibit