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Quinacrine (dihydrochloride hydrate)

Quinacrine (dihydrochloride hydrate)

产品编号 T23210   CAS T23210
别名: Quinacrine (hydrochloride hydrate) (83-89-6 free base)

Quinacrine is a compound that is commonly used as an anti-protozoal agent. It inhibits voltage-dependent sodium channels (IC50: 3.3 μM) and suppresses aldehyde oxidase (IC50: 3.3 μM). Quinacrine prevents misfolding of prion protein (EC50: 0.3 μM). As an effective riboflavin antagonist, quinacrine associates with the riboflavin-binding protein (Ki: 6.7 μM). Voltage-dependent sodium channels play a vital role in action potential initiation and propagation in excitable cells, including muscle, nerve, and neuroendocrine cell types.

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Quinacrine (dihydrochloride hydrate) Chemical Structure
Quinacrine (dihydrochloride hydrate), CAS T23210
规格 价格/CNY 货期 数量
100 mg ¥ 325 待询
500 mg ¥ 430 待询
1 g ¥ 547 待询

Quinacrine (dihydrochloride hydrate) 的其他形式现货产品:

Quinacrine dihydrochloride
其他形式的 Quinacrine (dihydrochloride hydrate):
千万补贴 助力科研
BCA蛋白浓度测定试剂盒限时半价
产品目录号及名称: Quinacrine (dihydrochloride hydrate) (T23210)
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存储 & 溶解度
产品描述 Quinacrine is a compound that is commonly used as an anti-protozoal agent. It inhibits voltage-dependent sodium channels (IC50: 3.3 μM) and suppresses aldehyde oxidase (IC50: 3.3 μM). Quinacrine prevents misfolding of prion protein (EC50: 0.3 μM). As an effective riboflavin antagonist, quinacrine associates with the riboflavin-binding protein (Ki: 6.7 μM). Voltage-dependent sodium channels play a vital role in action potential initiation and propagation in excitable cells, including muscle, nerve, and neuroendocrine cell types.
体外活性 Quinacrine, in a dose-dependent manner, effectively reversed the resistance in the multi-drug resistance (MDR) K562 cells. Quinacrine displayed strong toxicity to the MDR K562 cells at a concentration of 10.0 μM. Compared to the control, quinacrine significantly increased the activity of caspase-9 and -3 activities in the MDR K562 and K562 cells in a dose-dependent fashion [1].
体内活性 Female BALB/c nude mice, bearing MDR K562 cell xenografts, were injected with quinacrine at a dose of 10 mg/kg via tail vein for 13 days. Compared to the control group, quinacrine inhibited tumor growth obviously in the treated groups. Furthermore, quinacrine enhanced the anti-tumor effects of vincristine [1].
别名 Quinacrine (hydrochloride hydrate) (83-89-6 free base)
分子量 472.9
分子式 C23H30ClN3O·2HCl [XH2O]
CAS No. T23210

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度

H2O: ≥18.65mg/mL

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母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。

体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。

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Keywords

Quinacrine (dihydrochloride hydrate) T23210 Others Quinacrine (hydrochloride hydrate) Quinacrine Quinacrine (hydrochloride hydrate) (83-89-6 free base) 83-89-6 dihydrochloride Hydrate 83-89-6 free base Inhibitor inhibitor inhibit

 

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