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Neocuproine

产品编号 T33631 CAS 484-11-7

别名: Neocuproin

Neocuproine 是一种铜（I）螯合剂，可增强电场刺激引起的输精管收缩的嘌呤能成分，常被用作配位试剂和铜离子检测剂。Neocuproine 与铜离子形成稳定的络合物，并可在某些化学反应和分析方法中起到催化作用。Neocuproine 作为铁和钴上的氧化还原活性配体平台，对NSC34细胞氧化损伤的保护作用。

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Neocuproine, CAS 484-11-7

规格	价格/CNY		货期	数量
5 g	￥ 249		待询
10 g	￥ 418		待询

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生物活性

化学信息

存储 & 溶解度

参考文献

产品描述	Neocuproine is a copper(I) chelator that enhances the purinergic component of vasoconstriction induced by electric field stimulation, and is often used as a ligand reagent and copper ion detector.Neocuproine forms stable complexes with copper ions and can play a catalytic role in certain chemical reactions and analytical methods.Neocuproine acts as a redox-active on the iron and cobalt ligand platform for protection against oxidative damage in NSC34 cells.
体外活性	Neocuproine (100 lM) generally inhibits the production of inflammatory mediators.[2] Neocuproine treatment reduced IFN-γ, MCP-1, MCP-3, and VEGF-A levels. The production of KC/GRO was downregulated by neocuproine deficiency.[2] Neocuproine, but not ATP7A deficiency, reduced the production of FGF-9, IL-1α, IL-12p70, IL-2, IL-3, IL-4, IL-6, MIP-1β, MIP-2, RANTES, and TNFα.[2]
体内活性	Neocuproine (100 microM) significantly suppressed the amplitude and frequency of the spontaneous contractions in the ovariectomized non-pregnant rat uterus while this agent facilitated the frequency of the spontaneous or oxytocin-induced contractions in the pregnant rat and human uterus without altering the amplitude of these contractions.[3] Neocuproine (200 microM) could enhance the amplitude of the contractions in the pregnant uterus. These effects were blocked by a purinergic receptor antagonist, suramin (100 microM) and did not occur following the administration of neocuproine-copper(I) complex or copper(II) chelator cuprizone. alpha, beta-methylene ATP increased the amplitude and frequency of contractions in the pregnant uterus, but not affected the contractions in the ovariectomized non-pregnant rat uterus, and neocuproine potentiated this facilitation effect.[3]

别名	Neocuproin
分子量	208.26
分子式	C14H12N2
CAS No.	484-11-7

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度

DMSO: 45.0 mg/mL (216.1 mM), Sonication and heating to 60℃ are recommended.

溶液配制表

可选溶剂	浓度体积质量	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	4.8017 mL	24.0085 mL	48.0169 mL	120.0423 mL
	5 mM	0.9603 mL	4.8017 mL	9.6034 mL	24.0085 mL
	10 mM	0.4802 mL	2.4008 mL	4.8017 mL	12.0042 mL
	20 mM	0.2401 mL	1.2004 mL	2.4008 mL	6.0021 mL
	50 mM	0.096 mL	0.4802 mL	0.9603 mL	2.4008 mL
	100 mM	0.048 mL	0.2401 mL	0.4802 mL	1.2004 mL

计算器

摩尔浓度计算器

稀释计算器

配液计算器

分子量计算器

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参考文献

1. Castro PA, et al. Copper-uptake is critical for the down regulation of synapsin and dynamin induced by neocuproine: modulation of synaptic activity in hippocampal neurons. Front Aging Neurosci. 2014 Dec 3;6:319. 2. Patel OV, et al. Production of LPS-induced inflammatory mediators in murine peritoneal macrophages: neocuproine as a broad inhibitor and ATP7A as a selective regulator. Biometals. 2013 Jun;26(3):415-25. 3. Kumcu EK, et al. Differential effect of neocuproine, a copper(I) chelator, on contractile activity in isolated ovariectomized non-pregnant rat, pregnant rat and pregnant human uterus. Eur J Pharmacol. 2009 Mar 1;605(1-3):158-63. 4. Soares SAR, et al. Comparison of Spectrophotometric Methods for the Determination of Copper in Sugar Cane Spirit. J AOAC Int. 2018 May 1;101(3):876-882.

剂量换算

对于不同动物的给药剂量换算，您也可以参考 更多...

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10 只，您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL)，如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法：取 50 μL DMSO 主液，加入 300 μL PEG300，混匀澄清，再加 50 μL Tween 80，混匀澄清，再加 600 μL ddH2O, 混匀澄清。

第一步：请输入动物实验的基本信息

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第二步：请输入动物体内配方组成，不同的产品配方组成不同，如有配方需求，可先联系我们提供正确的体内配方。

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