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顶部相关产品产品介绍化学信息储存和溶解信息计算器

(Rac)-5-Hydroxymethyl Tolterodine hydrochloride

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货号 T40161Cas号 250214-40-5

别名 (Rac)-PNU-200577hydrochloride, (Rac)-Desfesoterodine hydrochloride, (Rac)-5-Hydroxymethyl Tolterodine hydrochloride

(Rac)-5-Hydroxymethyl Tolterodine hydrochloride, also known as (Rac)-Desfesoterodine hydrochloride, is an active metabolite of Tolterodine that functions as a mAChR antagonist. It exhibits significant affinity (K i values) for M1, M2, M3, M4, and M5 receptors, with values of 2.3 nM, 2 nM, 2.5 nM, 2.8 nM, and 2.9 nM, respectively. This compound is commonly employed in research related to overactive bladder conditions.

(Rac)-5-Hydroxymethyl Tolterodine hydrochloride
其他形式的 “(Rac)-5-Hydroxymethyl Tolterodine hydrochloride”:
5-Hydroxymethyl tolterodine formate
Desfesoterodine
(Rac)-5-Hydroxymethyl Tolterodine

(Rac)-5-Hydroxymethyl Tolterodine hydrochloride

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货号 T40161 别名 (Rac)-PNU-200577hydrochloride, (Rac)-Desfesoterodine hydrochloride, (Rac)-5-Hydroxymethyl Tolterodine hydrochlorideCas号 250214-40-5

(Rac)-5-Hydroxymethyl Tolterodine hydrochloride, also known as (Rac)-Desfesoterodine hydrochloride, is an active metabolite of Tolterodine that functions as a mAChR antagonist. It exhibits significant affinity (K i values) for M1, M2, M3, M4, and M5 receptors, with values of 2.3 nM, 2 nM, 2.5 nM, 2.8 nM, and 2.9 nM, respectively. This compound is commonly employed in research related to overactive bladder conditions.

规格价格库存数量
2 mg
¥ 1,150
5日内发货
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产品介绍

生物活性
产品描述
(Rac)-5-Hydroxymethyl Tolterodine hydrochloride, also known as (Rac)-Desfesoterodine hydrochloride, is an active metabolite of Tolterodine that functions as a mAChR antagonist. It exhibits significant affinity (K i values) for M1, M2, M3, M4, and M5 receptors, with values of 2.3 nM, 2 nM, 2.5 nM, 2.8 nM, and 2.9 nM, respectively. This compound is commonly employed in research related to overactive bladder conditions.
体外活性

In vitro, (Rac)-5-Hydroxymethyl Tolterodine (PNU-200577) hydrochloride produces a competitive and concentration-dependent inhibition of carbachol-induced contraction of guinea-pig isolated urinary bladder strips (K B of 0.84 nM; pA2 of 9.14)[2].

体内活性

(Rac)-5-Hydroxymethyl Tolterodine (5-HMT; 0.88 μmol/kg; i.v.) hydrochloride treatment shows the binding activity of (Rac)-5-Hydroxymethyl Tolterodine hydrochloride to muscarinic receptors is significantly observed in all tissues, except cerebral cortex, with a longer duration in bladder[3].

别名(Rac)-PNU-200577hydrochloride, (Rac)-Desfesoterodine hydrochloride, (Rac)-5-Hydroxymethyl Tolterodine hydrochloride
化学信息
分子量377.95
分子式C22H32ClNO2
CAS No.250214-40-5
SmilesCl.CC(C)N(CCC(c1ccccc1)c1cc(CO)ccc1O)C(C)C
储存&溶解度
存储Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

计算器

  • 摩尔浓度 计算器
  • 稀释 计算器
  • 配液 计算器
  • 分子量 计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：
TargetMol | Animal experiments 比如您的给药剂量是10 mg/kg，每只动物体重20g，给药体积100 μL， TargetMol | Animal experiments 一共给药动物10只，您使用的配方为5%TargetMol | reagent DMSO + 30%PEG300 + 5%Tween 80 + 60%Saline/PBS/ddH2O， 那么您的工作液浓度为2mg/mL。
母液配置方法: 2 mg 药物溶于 50 μLDMSOTargetMol | reagent （ 母液浓度为 40 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。
体内配方的制备方法: 取 50μLDMSOTargetMol | reagent 母液，添加 300 μLPEG300TargetMol | reagent 混匀澄清，再加 50μLTween80, 混匀澄清，再加 600μLSaline/PBS/ddH2OTargetMol | reagent 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO ， PEG300 / PEG400 ， Tween 80 ， SBE-β-CD ， 玉米油 等， 均可在TargetMol网站点击购买。
1 请输入动物实验的基本信息
mg/kg
g
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2 请输入动物体内配方组成，不同的产品配方组成不同，如有配方需求，可先联系我们提供正确的体内配方。
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

剂量转换

对于不同动物的给药剂量换算，您也可以参考 更多

关键词

PNU-200577hydrochlorideDesfesoterodine Hydrochloride5-Hydroxymethyl Tolterodine Hydrochloride(Rac)5Hydroxymethyl Tolterodine hydrochloride(Rac) 5 Hydroxymethyl Tolterodine hydrochloride
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