Galectin

Galectins are a class of proteins that bind specifically to β-galactoside sugars, such as N-acetyllactosamine (Galβ1-3GlcNAc or Galβ1-4GlcNAc), which can be bound to proteins by either N-linked or O-linked glycosylation. They are also termed S-type lectins due to their dependency on disulphide bonds for stability and carbohydrate binding. There have been about 15 galectins discovered in mammals, encoded by the LGALS genes, which are numbered in a consecutive manner. Only galectin-1, -2, -3, -4, -7, -7B, -8, -9, -9B, 9C, -10, -12, -13, -14, and -16 have been identified in humans. Galectin-5 and -6 are found in rodents, whereas galectin-11 and -15 are uniquely found in sheep and goats. Members of the galectin family have also been discovered in other mammals, birds, amphibians, fish, nematodes, sponges, and some fungi. Unlike the majority of lectins they are not membrane bound, but soluble proteins with both intra- and extracellular functions. They have distinct but overlapping distributions[2] but found primarily in the cytosol, nucleus, extracellular matrix or in circulation. Although many galectins must be secreted, they do not have a typical signal peptide required for classical secretion. The mechanism and reason for this non-classical secretion pathway is unknown.

Cat. No.	Product Name	CAS No.	Purity
T5121	TD139 化合物TD139	1450824-22-2	99.48%
TD139 是一种吸入型 galectin-3 抑制剂（Kd：14 nM）。
T16413	OTX008 化合物OTX008	286936-40-1	98.55%
OTX008 是半乳糖凝集素 1 选择性抑制剂。
T15372	GB1107 化合物GB1107	1978336-61-6	98.33%
GB1107 是一种有效的选择性 Galectin-3 抑制剂，Kd 为 37 nM。
T11346L	G3-C12 acetate(848301-94-0 free base) 化合物G3-C12 acetate	T11346L	95.09%
G3-C12 acetate shows anticancer activity. is a galectin-3 binding peptide, with Kd of 88 nM.
T38074	Thiodigalactoside 硫代半乳糖苷	51555-87-4	98%
Thiodigalactoside是一种具有口服活性的，有效的半乳凝素 (GAL) 抑制剂，对于 GAL-1 和 GAL-3 的 Kd 值分别为 24 μM，49 μM。Thiodigalactoside 是一种不可代谢的二糖，具有抗炎和抗癌活性。Thiodigalactoside 可显着降低饮食诱发的肥胖大鼠的体重增加...

Cat. No.

Product Name

CAS No.

Purity

Chemical Structure

T5121

TD139

化合物TD139

1450824-22-2

99.48%

TD139 是一种吸入型 galectin-3 抑制剂（Kd：14 nM）。

T16413

OTX008

化合物OTX008

286936-40-1

98.55%

OTX008 是半乳糖凝集素 1 选择性抑制剂。

T15372

GB1107

化合物GB1107

1978336-61-6

98.33%

GB1107 是一种有效的选择性 Galectin-3 抑制剂，Kd 为 37 nM。

T11346L

G3-C12 acetate(848301-94-0 free base)

化合物G3-C12 acetate

T11346L

95.09%

G3-C12 acetate shows anticancer activity. is a galectin-3 binding peptide, with Kd of 88 nM.

T38074

Thiodigalactoside

硫代半乳糖苷

51555-87-4

98%

Thiodigalactoside是一种具有口服活性的，有效的半乳凝素 (GAL) 抑制剂，对于 GAL-1 和 GAL-3 的 Kd 值分别为 24 μM，49 μM。Thiodigalactoside 是一种不可代谢的二糖，具有抗炎和抗癌活性。Thiodigalactoside 可显着降低饮食诱发的肥胖大鼠的体重增加...