首页 工具
登录
购物车
Galectin

Galectin

Galectins are a class of proteins that bind specifically to β-galactoside sugars, such as N-acetyllactosamine (Galβ1-3GlcNAc or Galβ1-4GlcNAc), which can be bound to proteins by either N-linked or O-linked glycosylation. They are also termed S-type lectins due to their dependency on disulphide bonds for stability and carbohydrate binding. There have been about 15 galectins discovered in mammals, encoded by the LGALS genes, which are numbered in a consecutive manner. Only galectin-1, -2, -3, -4, -7, -7B, -8, -9, -9B, 9C, -10, -12, -13, -14, and -16 have been identified in humans. Galectin-5 and -6 are found in rodents, whereas galectin-11 and -15 are uniquely found in sheep and goats. Members of the galectin family have also been discovered in other mammals, birds, amphibians, fish, nematodes, sponges, and some fungi. Unlike the majority of lectins they are not membrane bound, but soluble proteins with both intra- and extracellular functions. They have distinct but overlapping distributions[2] but found primarily in the cytosol, nucleus, extracellular matrix or in circulation. Although many galectins must be secreted, they do not have a typical signal peptide required for classical secretion. The mechanism and reason for this non-classical secretion pathway is unknown.
Cat. No. Product Name CAS No. Purity Chemical Structure
T79380 Galectin-3/galectin-8-IN-1
化合物 Galectin-3/galectin-8-IN-1
98%
Galectin-3/galectin-8-IN-1 (Compound 53) 是抑制Galectin-3和galectin-8C末端结构域的双重抑制剂,其Kd值分别为4.12 μM和6.04 μM。该化合物有效抑制MRC-5肺成纤维细胞的迁移,可用于癌症和组织纤维化的研究。
T79381 Galectin-3/galectin-8-IN-2
化合物 Galectin-3/galectin-8-IN-2
98%
Galectin-3/galectin-8-IN-2(Compound 57)是一种针对Galectin-3和galectin-8C末端结构域的双重抑制剂,其Kd值分别为12.8 μM和2.06 μM。该化合物能够抑制MRC-5肺成纤维细胞的迁移,适用于癌症和组织纤维化研究领域。
T82605 DB21, Galectin-1 Antagonist
化合物 DB21, Galectin-1 Antagonist
1623027-80-4 98%
DB21, Galectin-1 Antagonist 是一种用于抑制galectin-1 (GAL1)与细胞表面聚糖结合的二苯并呋喃缀合肽模拟物。在黑色素瘤、肺腺癌和卵巢癌模型中,该化合物能增强血管生成和肿瘤生长的抑制效果。
T74538 Galectin-3 antagonist 2
化合物 Galectin-3 antagonist 2
2921603-02-1 98%
Galectin-3,作为β-半乳糖苷特异性的识别蛋白(凝集素),具备促进B细胞前体急性淋巴细胞白血病(BCP-ALL)细胞迁移及耐受药物治疗的功能。
T38074 Thiodigalactoside
硫代半乳糖苷
51555-87-4 99.74%
Thiodigalactoside 是一种具有口服活性的,有效的半乳凝素 (GAL) 抑制剂,对于 GAL-1 和 GAL-3 的 Kd 值分别为 24 μM,49 μM。Thiodigalactoside 是一种不可代谢的二糖,具有抗炎和抗癌活性。Thiodigalactoside 可显着降低饮食诱发的肥胖大鼠的体重增...
T5121 TD139
化合物TD139
1450824-22-2 99.48%
TD139 是一种吸入型 galectin-3 抑制剂(Kd:14 nM)。
T15372 GB1107
化合物GB1107
1978336-61-6 98.33%
GB1107 是一种有效的选择性 Galectin-3 抑制剂,Kd 为 37 nM。
T16413 OTX008
化合物OTX008
286936-40-1 96.38%
OTX008 (PTX008) 是半乳糖凝集素 1 选择性抑制剂。
T11346L G3-C12 acetate(848301-94-0 free base)
化合物G3-C12 acetate
T11346L 98%
G3-C12 acetate(848301-94-0 free base) 显示出抗癌活性。是一种半乳糖凝集素 3 结合肽,Kd 为 88 nM。
Galectin-3/galectin-8-IN-1
T79380
Galectin-3/galectin-8-IN-1 (Compound 53) 是抑制Galectin-3和galectin-8C末端结构域的双重抑制剂,其Kd值分别为4.12 μM和6.04 μM。该化合物有效抑制MRC-5肺成纤维细胞的迁移,可用于癌症和组织纤维化的研究。
Galectin-3/galectin-8-IN-2
T79381
Galectin-3/galectin-8-IN-2(Compound 57)是一种针对Galectin-3和galectin-8C末端结构域的双重抑制剂,其Kd值分别为12.8 μM和2.06 μM。该化合物能够抑制MRC-5肺成纤维细胞的迁移,适用于癌症和组织纤维化研究领域。
DB21, Galectin-1 Antagonist
T82605
DB21, Galectin-1 Antagonist 是一种用于抑制galectin-1 (GAL1)与细胞表面聚糖结合的二苯并呋喃缀合肽模拟物。在黑色素瘤、肺腺癌和卵巢癌模型中,该化合物能增强血管生成和肿瘤生长的抑制效果。
Galectin-3 antagonist 2
T74538
Galectin-3,作为β-半乳糖苷特异性的识别蛋白(凝集素),具备促进B细胞前体急性淋巴细胞白血病(BCP-ALL)细胞迁移及耐受药物治疗的功能。
Thiodigalactoside
T38074
Thiodigalactoside 是一种具有口服活性的,有效的半乳凝素 (GAL) 抑制剂,对于 GAL-1 和 GAL-3 的 Kd 值分别为 24 μM,49 μM。Thiodigalactoside 是一种不可代谢的二糖,具有抗炎和抗癌活性。Thiodigalactoside 可显着降低饮食诱发的肥胖大鼠的体重增...
TD139
T5121
TD139 是一种吸入型 galectin-3 抑制剂(Kd:14 nM)。
GB1107
T15372
GB1107 是一种有效的选择性 Galectin-3 抑制剂,Kd 为 37 nM。
OTX008
T16413
OTX008 (PTX008) 是半乳糖凝集素 1 选择性抑制剂。
G3-C12 acetate(848301-94-0 free base)
T11346L
G3-C12 acetate(848301-94-0 free base) 显示出抗癌活性。是一种半乳糖凝集素 3 结合肽,Kd 为 88 nM。
联系我们
400-820-0310

上海市静安区江场三路238号8楼