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Galectin

Galectin

Galectins are a class of proteins that bind specifically to β-galactoside sugars, such as N-acetyllactosamine (Galβ1-3GlcNAc or Galβ1-4GlcNAc), which can be bound to proteins by either N-linked or O-linked glycosylation. They are also termed S-type lectins due to their dependency on disulphide bonds for stability and carbohydrate binding. There have been about 15 galectins discovered in mammals, encoded by the LGALS genes, which are numbered in a consecutive manner. Only galectin-1, -2, -3, -4, -7, -7B, -8, -9, -9B, 9C, -10, -12, -13, -14, and -16 have been identified in humans. Galectin-5 and -6 are found in rodents, whereas galectin-11 and -15 are uniquely found in sheep and goats. Members of the galectin family have also been discovered in other mammals, birds, amphibians, fish, nematodes, sponges, and some fungi. Unlike the majority of lectins they are not membrane bound, but soluble proteins with both intra- and extracellular functions. They have distinct but overlapping distributions[2] but found primarily in the cytosol, nucleus, extracellular matrix or in circulation. Although many galectins must be secreted, they do not have a typical signal peptide required for classical secretion. The mechanism and reason for this non-classical secretion pathway is unknown.
Cat. No. Product Name CAS No. Purity Chemical Structure
T5121 TD139
化合物TD139
1450824-22-2 99.48%
TD139 是一种吸入型 galectin-3 抑制剂(Kd:14 nM)。
T16413 OTX008
化合物OTX008
286936-40-1 98.55%
OTX008 是半乳糖凝集素 1 选择性抑制剂。
T15372 GB1107
化合物GB1107
1978336-61-6 98.33%
GB1107 是一种有效的选择性 Galectin-3 抑制剂,Kd 为 37 nM。
T11346L G3-C12 acetate(848301-94-0 free base)
化合物G3-C12 acetate
T11346L 95.09%
G3-C12 acetate shows anticancer activity. is a galectin-3 binding peptide, with Kd of 88 nM.
T38074 Thiodigalactoside
硫代半乳糖苷
51555-87-4 98%
Thiodigalactoside是一种具有口服活性的,有效的半乳凝素 (GAL) 抑制剂,对于 GAL-1 和 GAL-3 的 Kd 值分别为 24 μM,49 μM。Thiodigalactoside 是一种不可代谢的二糖,具有抗炎和抗癌活性。Thiodigalactoside 可显着降低饮食诱发的肥胖大鼠的体重增加...
TD139
T5121
TD139 是一种吸入型 galectin-3 抑制剂(Kd:14 nM)。
OTX008
T16413
OTX008 是半乳糖凝集素 1 选择性抑制剂。
GB1107
T15372
GB1107 是一种有效的选择性 Galectin-3 抑制剂,Kd 为 37 nM。
G3-C12 acetate(848301-94-0 free base)
T11346L
G3-C12 acetate shows anticancer activity. is a galectin-3 binding peptide, with Kd of 88 nM.
Thiodigalactoside
T38074
Thiodigalactoside是一种具有口服活性的,有效的半乳凝素 (GAL) 抑制剂,对于 GAL-1 和 GAL-3 的 Kd 值分别为 24 μM,49 μM。Thiodigalactoside 是一种不可代谢的二糖,具有抗炎和抗癌活性。Thiodigalactoside 可显着降低饮食诱发的肥胖大鼠的体重增加...