tyrosine phosphatase 1b

Stearic acid (Cetylacetic acid) 是长链饱和脂肪酸，存在于许多动植物油脂中。

Rhein-8-glucoside calcium (Rhein-8-glucoside calcium salt) salt 是一种从 Saussurea lappa 根的 EtOH 提取物中，分离得到的蒽醌类 hPTP1B 抑制剂，IC50值为11.5 μM，具有抗菌作用。

(Rac)-RK-682 是 RK-682 的外消旋体。(Rac)-RK-682 是一种蛋白质酪氨酸磷酸酶 (PTPases) 抑制剂。(Rac)-RK-682 抑制蛋白酪氨酸磷酸酶 1B (PTP-1B)、低分子量蛋白酪氨酸磷酸酶 (LMW-PTP)、细胞分裂周期 25B (CDC-25B)，IC50分别为 8.6 μM、12.4 μM 和 0.7 μM。

PTP1B-IN-22是一种蛋白酪氨酸磷酸酶1B (PTP1B)抑制剂，可抑制骨骼肌 L6肌管的葡萄糖摄取。

PTP1B-IN-2 是一种蛋白酪氨酸磷酸酶抑制剂，IC50=50 nM。

3-Epicorosolic acid has a potent inhibitory effect on Epstein-Barr virus early antigen (EBV-EA) induction, it has potential anti-inflammatory activities as well as cancer chemopreventive activity.3-Epicorosolic acid shows both potent α-glucosidase and pro

bpV(phen) is a potent protein tyrosine phosphatase (PTP) and PTEN inhibitor (IC50s: 343 nM, 920 nM, and 38 nM for PTP-β, PTP-1B, and PTEN).

JTT 551 can be used in the research of type 2 diabetes mellitus. JTT 551 is selective a protein tyrosine phosphatase 1B (PTP1B) inhibitor, with Kis of 0.22 μM and 9.3 μM for PTP1B and TCPTP (T-cell protein tyrosine phosphatase), respectively.

MSI-1436 is a selective, non-competitive the enzyme protein-tyrosine phosphatase 1B (PTB1B)inhibitor(IC50 of appr 1 μM)

MSI-1436 lactate is a selective, non-competitive the enzyme protein-tyrosine phosphatase 1B (PTB1B)inhibitor(IC50 of appr 1 μM)

PTP1B-IN-8 is a potent and selective inhibitor of protein tyrosine phosphatase-1B (PTP1B).

Masticadienonic acid 是一种来自 Chios 乳香胶的化合物，具有潜在的抗炎抗癌活，通过调节炎症反应、肠道屏障完整性和微生物群来减轻小鼠的结肠炎。Masticadienonic acid 是一种潜在的蛋白酪氨酸磷酸酶 1B (PTP1B) 抑制剂，可用于研究糖尿病。

Isotanshinone IIA, could non-competitively inhibit Protein Tyrosine Phosphatase 1B (PTP1B) activity with an IC50 0f 11.4 μM. is an abietane-type diterpene metabolite.

IONIS PTP1BRx (ISIS 404173) 为一种针对蛋白酪氨酸磷酸酶 1B (PTP-1B) 的反义抑制剂。该化合物展现出抗糖尿病的活性，适用于探究肥胖相关的胰岛素抵抗及2型糖尿病的研究。

bpV(bipy) hydrate 是一种能有效抑制磷酸肌醇 3-磷酸酶 (PTEN) 及蛋白酪氨酸磷酸酶PTP-β和PTP-1B的化合物，其IC50分别为18、60.3和164 nM。

PTP1B-IN-29 (Compound A2B5) 是一种磷酸酶 (phosphatase) 抑制剂，能够抑制蛋白酪氨酸磷酸酶 1B (PTP1B)、TCPTP 和 λPPase，其IC50值分别为 1.27 μM、4.38 μM 和 8.79 μM。PTP1B-IN-29 适用于糖尿病和肥胖症研究。

CX08005 是一种蛋白酪氨酸磷酸酶 1B 抑制剂，可减轻与非酒精性脂肪肝相关的肝脏脂质蓄积和微循环障碍。

Aquastatin A is a fungal metabolite originally isolated fromF. aquaeductuumthat has diverse biological activities.1It is active againstS. aureus(MIC = 32 μg/ml) and inhibits enoyl-acyl carrier protein reductase (Fabl; IC50= 3.2 μM) andS. aureusfatty acid synthesis (IC50= 3.5 μM).2Aquastatin A also inhibits the Na+/K+-ATPase and H+/K+-ATPase (IC50s = 7.1 and 6.2 μM, respectively), as well as protein tyrosine phosphatase 1B (PTP1B; IC50= 0.19 μM).1,3 1.Hamano, K., Kinoshita-Okami, M., Minagawa, K., et al.Aquastatin A, an inhibitor of mammalian adenosine triphosphatases from Fusarium aquaeductuum. Taxonomy, fermentation, isolation, structure determination and biological propertiesJ. Antibiot. (Tokyo)46(11)1648-1657(1993) 2.Kwon, Y.-J., Fang, Y., Xu, G.-H., et al.Aquastatin A, a new inhibitor of enoyl-acyl carrier protein reductase from Sporothrix sp. FN611Biol. Pharm. Bull.32(12)2061-2064(2009) 3.Seo, C., Soh, J.H., Oh, H., et al.Isolation of the protein tyrosine phosphatase 1B inhibitory metabolite from the marine-derived fungus Cosmospora sp. SF-5060Bioorg. Med. Chem. Lett.19(21)6095-6097(2009)

Ficusonolide exhibits significant antidiabetic activity through its interactions with dipeptidyl peptidase-IV (DPP-IV), protein tyrosine phosphatase 1B (PTP-1B), α-glucosidase, and α-amylase.

MY33-3 is a powerful and specific inhibitor of receptor protein tyrosine phosphatase (RPTP)β ζ, demonstrating an IC50 value of approximately 0.1 μM. Moreover, MY33-3 exhibits inhibitory activity against PTP-1B with an IC50 value of about 0.7 μM. Additionally, MY33-3 has been shown to effectively decrease ethanol consumption and alleviate neuroinflammation and cognitive dysfunction induced by Sevoflurane.

PTP1B-IN-13, a potent and selective inhibitor of Protein Tyrosine Phosphatase 1B (PTP1B), effectively targets the allosteric site, exhibiting an IC50 value of 1.59 μM.

PTP1B-IN-14 is a selective PTP1B inhibitor ( IC 50 = 0.72 μM) targeting the allosteric site.

bpV(phen) trihydrate 是一种有效的蛋白酪氨酸磷酸酶 (PTP) 和 PTEN 抑制剂（对于 PTP-β、PTP-1B 和 PTEN，IC50 值：343 nM、920 nM 和 38 nM）。

PTP1B-IN-3 diammonium is a highly effective and orally bioavailable inhibitor of the protein tyrosine phosphatase 1B (PTP1B) enzyme, with an IC50 value of 120 nM for both PTP1B and TCPTP. This compound exhibits potent antidiabetic and anticancer properties, as supported by extensive research [1] [2].