H-D-Phe-Pip-Arg-pNA hydrochloride, a chromogenic substrate, mimics the N-terminal segment of the A alpha chain of fibrinogen, the native substrate of thrombin. It displays specificity towards thrombin and is employed for quantifying antithrombin-heparin cofactor (AT-III). The utilization of H-D-Phe-Pip-Arg-pNA hydrochloride in the AT-III assay enables a sensitive, accurate, and straightforward measurement process.
Heparin (Nadroparin) calcium (MW 3600-5000) 是一种可与抗凝血酶 III (ATIII) 形成复合物的抗凝剂。此肝素-抗凝血酶 III 复合物能与凝血酶及其他活化的凝血因子 IX、X、XI 和 XII 结合,不可逆地使其失活,有效阻止纤维蛋白原转化为纤维蛋白。
Heparin calcium (MW 15000-19000) 是一款高效的抗凝剂,能通过与抗凝血酶 III (ATIII) 形成可逆的复合物——肝素-抗凝血酶 III 复合物。该复合物进一步与凝血酶以及其他活化的凝血因子如IX、X、XI 和 XII 结合,以不可逆的方式使它们失活,从而有效防止纤维蛋白原转变为纤维蛋白。
pGlu-Pro-Arg-MNA monoacetate, a thrombin substrate modeled after a thrombin cleavage site in human fibrinogen, can be used for sensitive assays of antithrombinIII activity.