Thioredoxinreductasepeptide, corresponding to residues 53–67 in thioredoxinreductase (TrxR), is used in thioredoxinreductase research. Mammalian thioredoxinreductase (TR) catalyzes the reduction of the redox-active disulfide bond of thioredoxin (Trx) and is essential for cellular redox homeostasis.